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ADHD Medication Switching for Patients with Aggression or Mood Changes Secondary to Current Medication: Review of Clinical Effectiveness and Guidelines

Last updated: September 15, 2015
Project Number: RC0701-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Summary with Critical Appraisal
Result type: Report

Question

  1. What is the clinical effectiveness and safety of switching to another ADHD medication for patients who experience aggression or mood changes secondary to therapy with methylphenidate immediate-release (IR), methylphenidate sustained-release (SR), dextroamphetamine IR, or dextroamphetamine SR?
  2. What are the evidence-based guidelines regarding switching to another ADHD medication for patients who experience aggression or mood changes secondary to therapy with methylphenidate IR, methylphenidate SR, dextroamphetamine IR, or dextroamphetamine SR?

Key Message

No evidence regarding the clinical effectiveness or safety of switching ADHD medications following stimulant-related aggression or mood changes was identified. One evidence-based guideline suggested switching to atomoxetine in this clinical situation, however, the evidence for this recommendation was limited.