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Antidepressants for Adults with Depression using Opioid Medications: Clinical Effectiveness and Guidelines

Last updated: February 16, 2018
Project Number: RB1196-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Summary of Abstracts
Result type: Report

Question

  1. What is the clinical effectiveness of antidepressants in adults with depression using opioid medications?
  2. What are the evidence-based guidelines informing the use of antidepressants in adults with depression using opioid medications?

Key Message

Two systematic reviews, one meta-analysis, four randomized controlled trials, and one evidence-based guideline was identified regarding the clinical effectiveness of antidepressants in adults with depression using opioid medications.