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Benzydamine for the Treatment of Oropharyngeal Mucositis from Radiation Therapy: A Review of Clinical Effectiveness and Guidelines

Last updated: September 27, 2018
Project Number: RC1021-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Summary with Critical Appraisal
Result type: Report

Question

  1. What is the clinical effectiveness of benzydamine oral rinse (
  2. 15%) for the symptomatic relief of oropharyngeal mucositis caused by radiation therapy?
  3. What are guidelines informing the use of benzydamine oral rinse (
  4. 15%) for the symptomatic relief of oropharyngeal mucositis caused by radiation therapy?

Key Message

There is no evidence supporting the clinical effectiveness of benzydamine oral rinse for treatment of oropharyngeal mucositis caused by radiation therapy. A high quality systematic review identified two poor quality randomized controlled trials; these studies did not show a difference between benzydamine and placebo for improvement in oral mucositis. Available guidelines for the management of mucositis secondary to cancer therapy did not address the use of benzydamine oral rinse for treatment of oropharyngeal mucositis.