- What is the clinical effectiveness and safety of buprenorphine for the treatment of adults with chronic pain?
- What is the comparative clinical effectiveness of buprenorphine doses greater than 24 mg per day compared with daily doses of 24 mg or less?
- What is the clinical effectiveness of buprenorphine when tapering opioid doses for adults with chronic pain?
Buprenorphine results in modest reductions in pain in adults with chronic non-cancer pain, relative to placebo. There is no evidence that other opioids are superior to buprenorphine for treating chronic non-cancer pain.No relevant evidence was identified regarding the use of buprenorphine at doses greater than 24 mg per day, or when tapering opioid doses for adults with chronic pain.