CADTH Weekly COVID-19 Update

CADTH is committed to supporting Canada’s health care decision-makers through this challenging and uncertain time.

Our COVID-19 evidence portal contains the latest COVID-19 information from CADTH and other respected organizations. Content is updated daily to reflect the rapidly changing and growing state of the international scientific evidence related to this disease.

The following is a summary of the most recent information posted to our COVID-19 portal.

Events

PREVIOUSLY RECORDED WEBINAR: Surviving the COVID-19 Infodemic – Can You Trust Dr. Google? (June 23, 2020)

Reports

Gabapentin, Phenobarbital, Diazepam, and Lorazepam for the Treatment of Alcohol Withdrawal: Clinical Effectiveness and Guidelines

• We conducted a review on the clinical effectiveness of using gabapentin, phenobarbital, diazepam, or lorazepam to treat alcohol withdrawal.
• We also searched for evidence-based guidelines for treating alcohol withdrawal in the emergency department, and evidence-based guidelines for providing addiction services to vulnerable populations experiencing alcohol withdrawal during a pandemic.
• While no guidelines were identified regarding managing alcohol withdrawal during a pandemic, literature was identified regarding pharmaceutical options for treating alcohol withdrawal. Guidelines for treating alcohol withdrawal in the emergency department were also identified.

Ongoing Trials of Plasma-Based Therapies for the Treatment of COVID-19

• This report provides information on ongoing randomized controlled trials of intravenous immune globulin and hyperimmune globulin being investigated for the treatment of COVID-19.
• It will be updated every two weeks.
• Ongoing trials of convalescent plasma are addressed in separate CADTH reports.

Ongoing Trials for Bacille Calmette-Guérin (BCG) Vaccines in the Prevention of COVID-19

• This report provides information on ongoing clinical trials of BCG vaccines being investigated for the prevention of COVID-19.
• It will be updated every two weeks.
• Ongoing trials of novel vaccines for COVID-19 are addressed in a separate CADTH report.

Ongoing Trials for Novel Vaccines in the Prevention of COVID-19

• This report provides information on ongoing clinical trials of novel vaccines being investigated for the prevention of COVID-19.
• It will be updated every two weeks.
• Ongoing trials of Bacille Calmette-Guérin (BCG) vaccines are addressed in a separate CADTH report.

CADTH Literature Searching Tools

To help conduct your COVID-19–related literature searches, access our COVID-19 Search Strings and our COVID-19 Grey Literature Resources.

Additional Resources

CADTH is pleased to showcase additional COVID-19 resources from our partner organizations, as well as from the Canadian federal, provincial, and territorial governments’ health jurisdictions:

• Pan-Canadian Health Organizations
• Federal, Provincial, and Territorial Information

Can't Find What You Need? Let Us Know.

Canadian ministries and departments of health, publicly funded organizations responsible for health service delivery, and clinical society stakeholders are encouraged to submit a request or contact their CADTH Liaison Officer. We’re here to help.

The CADTH Weekly COVID-19 Update is intended to keep you informed about the latest information posted on the CADTH COVID-19 portal. You’re receiving this update because you’ve subscribed to our CADTH e-alert system.