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Cancer Surveillance for Family Members of Patients with Colorectal Cancer with or without Mismatch Repair Deficiency: A Review of the Clinical Evidence

Last updated: July 6, 2015
Project Number: RC0678-000
Product Line: Rapid Response
Research Type: Other Diagnostics
Report Type: Summary with Critical Appraisal
Result type: Report

Question

  1. What is the clinical effectiveness of surveillance of family members of colorectal cancer patients with Lynch Syndrome or mismatch repair deficient tumours?
  2. What is the clinical effectiveness of surveillance of family members of mismatch repair proficient colorectal cancer patients?
  3. What is the comparative clinical effectiveness of surveillance of family members of colorectal cancer patients with Lynch Syndrome or mismatch repair deficient tumours compared with those who are proficient?

Key Message

Surveillance was associated with decreased risk of colorectal and extra-colonic cancers, early cancer detection, and better survival in members of HNPCC families, regardless of mutation status. No evidence could be found regarding surveillance of family members of mismatch repair proficient colorectal cancer patients.During surveillance, higher rates of colorectal and other cancers were detected in mutation carriers (mutation positive) or members of Lynch syndrome families compared with non-mutation carriers (mutation negative) or members of non-Lynch syndrome families, respectively. There was no difference in the risk of mortality between mutation positive and mutation negative individuals, which suggests a potential benefit of screening for Lynch Syndrome for family members.