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Clopidogrel and Proton Pump Inhibitor Use: A Review of the Evidence on Safety

Last updated: March 14, 2017
Project Number: RC0874-000 - RD0036-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Summary with Critical Appraisal
Result type: Report

Question

  1. What are the harms of proton pump inhibitors used concomitantly with clopidogrel for patients requiring antiplatelet therapy following percutaneous coronary intervention?

Key Message

Although the findings across the studies were mixed, overall, the evidence favours clopidogrel antiplatelet therapy without PPIs. The evidence suggests that there are still some serious safety risks associated with the use of proton pump inhibitors (PPIs) with clopidogrel antiplatelet therapy (with or without aspirin) in patients following percutaneous coronary intervention (PCI) stent implantation.