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Codeine for Acute Pain in Patients Undergoing Orthopedic Surgery: A Review of Clinical Effectiveness

Last updated: October 29, 2019
Project Number: RC1199-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Summary with Critical Appraisal
Result type: Report

Question

  1. What is the clinical effectiveness of codeine for patients who have undergone orthopedic surgery?
  2. What is the clinical effectiveness of codeine with acetaminophen for patients who have undergone orthopedic surgery?

Key Message

Two systematic reviews on pharmacotherapies for the management of pain after orthopedic surgery were identified but did not contain any relevant literature regarding the clinical effectiveness of codeine, or codeine with acetaminophen, for pain management in patients who have undergone orthopedic surgery.