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Combination Use of Insulin and Dipeptidyl Peptidase-4 (DPP-4) Inhibitors in Type 2 Diabetes: Cliniical Effectiveness

Last updated: July 8, 2014
Project Number: RB0699-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Summary of Abstracts
Result type: Report

Question

  1. What is the clinical efficacy and safety of dipeptidyl peptidase-4 (DPP-4) inhibitors used incombination with insulin for patients with inadequate glycemic control on a basal or biphasicinsulin regimen?

Key Message

Four systematic reviews and seven randomized controlled trials were identified regarding the clinical efficacy and safety of DPP-4 inhibitors used in combination with insulin for patients withinadequate glycemic control on a basal or biphasic insulin regimen.