Computed Tomography Derived Fractional Flow Reserve for the Diagnosis of Coronary Artery Disease

Details

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Project Status:
Completed
Project Line:
Health Technology Review
Project Sub Line:
Rapid Review
Project Number:
RC1389-000

Question

  1. What is the diagnostic accuracy of computed tomography-derived fractional flow reserve (CT-FFR) analysis for the diagnosis of coronary artery disease in patients with stable chest pain?2.What is the clinical utility of CT-FFR analysis for the diagnosis of coronary artery disease in patients with stable chest pain?3.What is the cost-effectiveness of CT-FFR analysis for the diagnosis of coronary artery disease in patients with stable chest pain?

Key Message

Computed tomography-derived fractional flow reserve (CT-FFR) may predict coronary artery disease or flow-limiting stenosis in adult patients with stable chest pain better than coronary CT angiography alone, based on the relevant studies in 2 systematic reviews.CT-FFR is associated with a decreased need for invasive coronary angiography and revascularization in adult patients with stable chest pain, based on findings from 1 systematic review.In the US settings, CT-FFR was dominant (i.e., less costly and more effective) compared to stress testing for the evaluation of low-risk stable chest pain, based on findings from 1 cost-effectiveness study.