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Digital Tomosynthesis for the Screening and Diagnosis of Breast Cancer: Diagnostic Accuracy, Cost-Effectiveness, and Guidelines

Last updated: June 11, 2019
Project Number: RB1351-000
Product Line: Rapid Response
Research Type: Devices and Systems
Report Type: Summary of Abstracts
Result type: Report

Question

  1. What is the clinical effectiveness of 3D digital tomosynthesis with or without 2D mammography compared with 2D mammography alone for breast cancer diagnosis?
  2. What is the diagnostic accuracy of 3D digital tomosynthesis with or without 2D mammography compared with 2D mammography alone for breast cancer diagnosis?
  3. What is the comparative clinical effectiveness of synthetic 2D mammography compared with conventional 2D digital mammography obtained with 3D digital tomosynthesis?
  4. What is the cost effectiveness of 3D digital tomosynthesis with or without 2D mammography compared with 2D mammography alone for breast cancer screening or diagnosis?
  5. What are the evidence-based guidelines regarding the use of 3D digital tomosynthesis for breast cancer screening and diagnosis?

Key Message

Seven systematic reviews (four with meta-analyses), two randomized controlled trials, forty-four non-randomized studies, and three economic evaluations were identified regarding the clinical and cost-effectiveness of digital tomosynthesis compared with mammography for breast cancer screening and diagnosis. In addition, two evidence-based guidelines were identified regarding the use of digital tomosynthesis for breast cancer screening and diagnosis.