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Direct Observational Therapy for the Treatment of Tuberculosis: Clinical Evidence and Guidelines

Last updated: May 12, 2020
Project Number: RB1475-000
Product Line: Rapid Response
Report Type: Summary of Abstracts
Result type: Report

Question

  1. What is the clinical evidence regarding the provision of direct observational therapy for the treatment of tuberculosis?
  2. What are the evidence-based guidelines regarding the use of direct observational therapy for the treatment of tuberculosis?

Key Message

Eight systematic reviews (seven with meta-analyses), five randomized controlled trials and eight non-randomized studies were identified regarding the provision of direct observation therapy for treatment of tuberculosis. Additionally, eight evidence-based guidelines were identified regarding the use of direct observational therapy for the treatment of tuberculosis.