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Dissolution Techniques for Buprenorphine and Buprenorphine-Naloxone: Clinical Effectiveness and Guidelines

Last updated: September 24, 2019
Project Number: RA1074-000
Product Line: Rapid Response
Research Type: Devices and Systems
Report Type: Reference List
Result type: Report

Question

  1. What is the comparative clinical effectiveness of sublingual buprenorphine tablets administered using dissolution practices versus standard administration of buprenorphine for the treatment of opioid use disorder or dependency?
  2. What is the comparative clinical effectiveness of sublingual buprenorphine-naloxone tablets administered using dissolution practices versus standard administration of these drugs for the treatment of opioid use disorder or dependency?
  3. What are the evidence-based guidelines regarding the dissolution of buprenorphine or buprenorphine-naloxone combination tablets for the treatment of opioid use disorder or dependency?

Key Message

No literature was identified regarding the comparative clinical effectiveness of sublingual buprenorphine or buprenorphine-naloxone tablets administered using dissolution practices versus standard administration for the treatment of opioid use disorder or dependency. Furthermore, no evidence-based guidelines were identified regarding the dissolution of buprenorphine or buprenorphine-naloxone combination tablets for the treatment of opioid use disorder or dependency.