(disponible en anglais seulement)
- Inflammatory bowel disease (IBD) includes Crohn’s disease and ulcerative colitis — lifelong conditions that can cause disabling symptoms, serious complications, and increased risk of death.
- People with IBD have reduced diversity of naturally occurring bacteria and other microorganisms, and this may be a key aspect of the disease.
- Fecal microbiota transplantation (FMT) is the transfer of filtered fecal material from a healthy donor. Because FMT has been successful in treating some cases of Clostridium difficile (C. difficile) infection, it is being explored for the treatment of IBD.
- The evidence for FMT in IBD includes two recent systematic reviews and six subsequent studies, including two randomized controlled trials (RCTs). Several other trials are underway.
- Experts agree that, although FMT shows promise, current clinical evidence does not support its use for the treatment of IBD.
IBD includes Crohn’s disease and ulcerative colitis. These chronic relapsing conditions are caused by inflammatory reactions that can damage the gastrointestinal tract.1 The symptoms experienced during relapses depend on the segment of the intestinal tract involved, and range from mild to severe.2 Ulcerative colitis is generally limited to the superficial layers of the large bowel; if untreated, it can lead to frequent bloody stools, toxic megacolon, and colorectal cancer.3 Crohn’s disease can involve any part of the gastrointestinal tract and can cause diarrhea, abdominal pain, fatigue, and malnutrition.3 Crohn’s disease can also have extraintestinal manifestations such as arthritis, liver disease, and growth impairment in children.4
The gastrointestinal tract is exposed to countless antigens, including both safe and disease-causing micro-organisms, and the immune system must discriminate among them.5 The micro-organisms (“microbiota”) include more than 1,000 species of bacteria plus fungi, parasites, and viruses that play a key role in nutrition, energy metabolism, host defense, and immune system development.6-9 Compared with healthy people, patients with IBD have reduced microbiota diversity, and some researchers feel that this may make the gut less adaptable to environmental changes and natural disturbances.1,10-12
Manipulation of the microbiota has emerged as a possible treatment for IBD, including interventions such as diet, prebiotics, probiotics, antibiotics, and FMT.1 An older therapy that has recently been rediscovered, FMT aims to restore a healthy intestinal microbial community in a patient via the infusion of a filtrate of feces from a healthy donor.8,13 Donor feces are diluted with a liquid such as water or saline and strained to remove large particles. The resulting suspension is introduced into the recipient’s gut via an upper gastrointestinal route (e.g., nasogastric tube or endoscope) or via a lower gastrointestinal route (e.g., rectal enema or working channel of a colonoscope).12,14
FMT has shown very high cure rates for recurrent C. difficile infection, regardless of the recipient, donor, or delivery method.7,15,16 This may be due to correction of the relatively depleted, homogeneous intestinal microbiota that facilitated the growth of toxic organisms.11 FMT may therefore be a promising approach for the management of other gastrointestinal diseases such as IBD.1,8,10,12,16
Health Canada considers FMT to be an “investigational new biologic drug”. For all indications other than the treatment of C. difficile infection, FMT must be used within a clinical trial that is authorized by Health Canada. A clinical trial application is not required if FMT is used for the treatment of unresponsive C. difficile infection, although sponsors must submit a notification to Health Canada’s Biologics and Genetic Therapies Directorate, including informed consent of the patients.17
The US Food and Drug Administration (FDA) classifies human feces as a biological agent and has determined that its use in FMT therapy and other research should be regulated to ensure patient safety. The FDA is in the process of developing policy for the study and use of FMT therapy, primarily for C. difficile.18 The use of FMT is not regulated in the European Union, including the United Kingdom.15,19,20
IBD is common in Western industrialized countries, generally affecting about 0.4% of the population.11 Its incidence is increasing in developing countries, possibly due to changing dietary habits and the related effects on microbiome composition.1,2 In 2012 there were an estimated 233,000 people with IBD in Canada (129,000 with Crohn’s disease and 104,000 with ulcerative colitis) with an average incidence of 16.3 new cases of Crohn’s disease and 12.9 new cases of ulcerative colitis per 100,000 people, or an estimated 10,200 new cases of IBD annually.21
Both diseases are thought to result from a combination of genetics, environment, and a dysfunctional host immune system.1,8,22 Concordance rates in monozygotic twins of 16% for ulcerative colitis and 35% for Crohn’s disease suggest factors beyond genetics, in particular, the environment, may contribute significantly to the natural history of disease.1,22,23 Studies in different ethnic groups show an interaction between genetics and environment; for example, if a child moves from a lowincidence population in a developing country to a developed country where incidence rates are higher, the likelihood of IBD increases as the child ages.2 The evidence that environmental factors play a role has led to interest in treatment strategies designed to modify the environment, including FMT.
Ileocolonoscopy is the gold standard for the diagnosis of IBD. Magnetic resonance imaging (MRI) can be an attractive supplementary option to monitor treatment because it is relatively non-invasive, does not expose the patient to ionizing radiation, and requires minimal bowel preparation.3,24
There is currently no cure for IBD. Current treatment practice focuses on the management of inflammation rather than management of an underlying cause.11 Treatment goals include: control of symptoms with minimal use of corticosteroids; biological remission (normalization of inflammatory biomarkers); endoscopic remission (mucosal healing); and prevention of disease-related complications, disability, and death.25 Treatment decisions are based on disease location and severity, complications, individual symptomatic response, tolerance to medical intervention, and patient access to diagnostic and treatment options.2
Drug treatment typically involves initial therapy followed by long-term maintenance. Conventional treatment algorithms feature sequential use of anti-inflammatory and immunemodulating drugs including aminosalicylates, corticosteroids, immune modifiers such as methotrexate, and tumour necrosis factor alpha antagonists such as infliximab.22,26 However, these drugs have numerous side effects (notably an increased risk of infection), cannot be administered orally, and can be very costly.1,2
The conventional management approach has been progressive intensification of therapy as the disease worsens, although more aggressive therapy at an earlier stage of disease may improve clinical outcomes.25 Current drug treatment is imperfect, with some patients showing only modest gains and others showing minimal responses.27,28 Surgery to remove or temporarily bypass parts of the intestine, plus other procedures such as abscess drainage, is required for 55% to 75% of patients with Crohn’s disease and up to 30% of those with ulcerative colitis.2,24
Literature Search Strategy
A peer-reviewed literature search was conducted using the following bibliographic databases: MEDLINE, PubMed, Embase, and The Cochrane Library. Grey literature was identified by searching relevant sections of the CADTH Grey Matters checklist (http://www.cadth.ca/resources/grey-matters). No methodological filters were applied. The search was limited to English language documents published between January 1, 2013 and June 8, 2015, and selections were further limited to FMT in patients with IBD but without C. difficile. Regular alerts were established to update the search until August 31, 2015.
The evidence included two systematic reviews of FMT for IBD (Table 1)29,30 and six more recent studies (Table 2) of FMT treatment in patients with IBD not accompanied by C. difficile.28,31-35 The literature searches for the two systematic reviews ended in July 201329 and May 2014.30 Despite the number of studies included in these reviews (n = 7 and n = 18), the total patient numbers were low. A little more than 100 patients were included in each review, with most patients affected by ulcerative colitis and few (5% to 35%) affected by Crohn’s disease.
The review of 18 studies30 included nine prospective, uncontrolled, cohort studies, eight retrospective case studies or case reports, and one RCT. The studies included both adults and children (Table 1). Of the 122 patients included in the systematic review, 79 (65%) had ulcerative colitis, 39 (32%) had Crohn’s disease, and four (3%) had unclassified IBD. Overall, clinical remission was achieved by 45% of patients. The authors conducted a meta-analysis of the nine cohort studies (70 patients). Follow-up was short, with only four of nine studies following patients for three months or longer.
Table 1: Included Systematic Reviews of Fecal Microbiota Transplantation for Inflammatory Bowel Disease
|Authors (Year); Author Location(s); Literature Search End||Included Studies||Patients||Outcomes|
|Colman and Rubin (2014);30 US; literature search ended May 2014; no language restrictions||18 studies: 1 RCT,
9 cohort, 8 case studies
|n = 122: 79 w/ UC,
39 w/ CD, and 4 w/ IBD
|Overall, 45% of patients achieved CR; MA of cohort studies (i.e., case studies excluded) reported 36% CR (UC 22%, CD 61%)|
|Rossen et al. (2015);29 Netherlands, Canada, and Finland; literature search ended July 2013; restricted to English language studies||7 cohort studiesa||n = 112: 106 w/ UC
(4 had concomitant CDI) and 6 w/ CD
|In UC, CR rates were 0% to 68%;
in CD, no benefit was observed
CD = Crohn’s disease; CDI = Clostridium difficile infection; CR = clinical remission; FMT = fecal microbiota transplantation; IBD = inflammatory bowel
disease; MA = meta-analysis; RCT = randomized controlled trial; SR = systematic review; UC = ulcerative colitis; w/ = with.
a Overlap of five studies, i.e., five of the seven studies in Rossen et al. (2015) were among the 18 included in Colman and Rubin (2014).
The route of administration varied among studies as did the number of treatments. Meta-analysis results showed that the pooled proportion of patients who achieved clinical remission was 36% (95% confidence interval [CI], 17.4% to 60.4%). Subgroup analyses of the cohort studies by disease reported 22% clinical remission for patients with ulcerative colitis (95% CI, 10.4% to 40.8%) and 61% clinical remission for patients with Crohn’s disease (95% CI, 28.4% to 85.6%), although the patient group with Crohn’s disease across studies was small (n = 39). The authors noted that this technology is in its infancy, and more research is needed to determine the optimal treatment route, frequency and timing, as well as donor and microbiota characteristics.
The other systematic review was broader overall, examining FMT in gastrointestinal disease.29 The subanalysis related to FMT in IBD included seven cohort studies (five of which were captured in the previously described review). The total number of patients was 112 with 95% having ulcerative colitis. Followup was generally at least three months (ranging from one to 198 months). All seven studies reported on clinical improvement (not clearly defined), with only four reporting on clinical remission. Clinical improvement ranged from 0% in a very small study of four patients with refractory Crohn’s disease to 68% in a larger study of 62 patients with active ulcerative colitis. The four studies addressing clinical remission reported rates of 0% in two small studies of patients with refractory disease (one for Crohn’s disease, one for ulcerative colitis) to 30% and 68% in two studies of patients with active ulcerative colitis. Endoscopic follow-up was employed in some of the studies, but these results were not reported. The authors concluded that patients with IBD should be treated with FMT only in the setting of clinical trials, due to the paucity of evidence in this patient group.
More Recent Studies
Six studies were published after the end of the literature searches for the two included systematic reviews: two doubleblind RCTs,28,34,36,37 one comparative cohort study,31 and three case series studies (Table 2).32,33,35 Three studies were published only as conference abstracts.31-33 The three comparative studies are discussed in more detail in the following paragraphs.28,37,38
The two RCTs were limited to patients with ulcerative colitis. In both trials, patients in the intervention group received FMT, but administration routes varied (retention enema versus nasogastric tube), as did the frequency of administration (once weekly for six weeks versus at weeks 0 and 3) and the drug regimens of enrolled patients. In both cases, FMT was prepared from donated feces from healthy volunteers.
- One of the two RCTs was a Canadian trial conducted at three sites in Hamilton, Ontario.28,36 The primary outcome was clinical remission at week 7, defined as a favourable Mayo score (a composite of stool frequency, rectal bleeding, endoscopy findings, and physician global assessment) and complete healing of the mucosa. Of 75 adults enrolled, 70 completed the study with approximately equal withdrawals from each group (three in the FMT group and two in the control group). Patients received FMT (n = 37) or water only (n = 38) via retention enema once a week for six weeks. Patients, clinicians, and investigators were blinded to group assignment. There was no pre-intervention bowel lavage or antibiotic treatment. Results showed a statistically significant FMT benefit, with clinical remission at week 7 for nine of 38 (24%) patients in the FMT group versus two of 37 (5%) in the placebo group (P = 0.03). At longer follow-up (nine to 12 months), eight of the nine FMT group patients who were in clinical remission at week 7 remained in remission. Four patients were able to stop all medications and three patients continued with monthly FMT. Secondary outcomes between study groups were not statistically significant, including the proportions of patients with symptom improvement, quality of life scores, and serious adverse events (SAEs). Unfortunately, although enrolment was planned for 130 patients over 18 months, the study’s Data Monitoring and Safety Committee terminated the trial at the halfway point because the trial did not meet its stated objectives, i.e., the difference between groups in the primary outcome (clinical remission) did not achieve statistical significance, nor did any of the secondary end points.
- The other RCT was conducted at a single centre in the Netherlands.34,37 Adults with mild to moderate ulcerative colitis were randomized 1:1 to receive an infusion via nasogastric tube of donor FMT (n = 23) or their own fecal material (n = 25) after pre-FMT bowel lavage at the start of the study and three weeks later. Follow-up at 12 weeks included clinical and endoscopic assessment. Results showed no significant difference in rates of clinical remission and endoscopic response between groups (intention-to-treat analysis 30% versus 20%, P = 0.51; per-protocol analysis 41% versus 25%, P = 0.29, for FMT versus controls, respectively). SAEs occurred in two patients in each group but were not considered to be related to the FMT. This trial was also stopped by the study’s Data Monitoring and Safety Committee after the second interim analysis.
- A 12-week, open-label, comparative pilot study from Italy enrolled 15 patients with mild to moderate ulcerative colitis (FMT via colonoscopy = 8, standard therapy = 7).31 Feasibility and patient acceptance were of primary interest and, although two patients from each study group dropped out due to disease worsening, the authors concluded that the procedure was safe and well tolerated. For secondary outcomes, clinical remission occurred in 38% of patients in the FMT group versus 29% in those receiving standard therapy, and clinical response occurred in 50% versus 29% of patients (no statistics were reported).
ClinicalTrials.gov lists five studies (planned or underway) in adults with IBD, including four RCTs (Table 3). In addition, there is research published and underway in children with IBD.
Table 2: Additional Individual Studies
|Authors (Year), Location||Publication Type||Patients and Treatment||Outcomes|
|Moayyedi et al. (2015),28,36 Canada (Hamilton, ON)a||Journal article (and conference abstract)||n = 75 pts w/ UC (FMT = 38,
PL = 37); 50 mL infusion of donor FMT in water as a retention enema vs. water only for placebo group once weekly x 6
|CR induced at 7 weeks: FMT 24% vs. PL 5%; 95% CI, 2% to 33%
RCT was stopped by the DMSC before completion
|Rossen et al. (2015),34,37 Netherlands||Journal article (and conference abstract)||n = 48 pts w/ UC (FMT = 23,
PL = 25); 50 mL infusion of 60 g donor FMT in water via NG tube vs. patient’s own stool in water for placebo group, given at outset and 3 weeks later
|No SS difference between groups after 12 weeks (ITT analysis: 30% vs. 20%; P = 0.51; PP analysis: 41% vs.
25%; P = 0.29)
RCT was stopped by the DMSC before completion
|Scaldaferri et al. (2015),31 Italy||Conference abstract||n = 15 pts w/ mild–moderate UC (FMT = 8, ST = 7)||CR induced at 12 weeks: FMT 38% vs. ST 29% (no statistics reported)|
|Cui et al. (2015),35 China||Journal article||n = 30 pts w/ refractory CD||60% had CR at 6 months (peak CR was 70% at 3 months)|
|Ren et al. (2014),32 China||Conference abstract||n = 4 pts w/ refractory IBD||100% had CR to different extents (no detail was provided)|
|Vaughn et al. (2014),33 US||Conference abstract||n = 8 pts w/ active CD||5 of 8 (62%) in CR at 4 weeks: 4 of 4
(100%) in CR at 8 weeks
CD = Crohn’s disease; CI = confidence interval; CR = clinical remission; DMSC = Data Monitoring and Safety Committee; FMT = fecal microbiota transplantation; IBD = inflammatory bowel disease; ITT = intention-to-treat; NG = nasogastric; PL = placebo; PP = per-protocol; pts = patients; RCT = randomized controlled trial; SR = systematic review; SS = statistically significant; ST = standard therapy; UC = ulcerative colitis; vs. = versus; w/ = with.
a An earlier report of this study with n = 53 (included in the Colman and Rubin SR) showed no statistically significant difference in outcomes between study groups.
FMT was generally well tolerated and authors described the treatment as safe, although not as safe as the experience showed for FMT in patients with C. difficile infection.20,22 Common adverse events (AEs) included fever, an increase in C-reactive protein (an indication of inflammation in response to infection), diarrhea, and vomiting.22 However, due to the sparse amount of evidence available to date, experts have questioned the long-term consequences of FMT with regards to infection, cancer, and autoimmune and metabolic diseases.27 Both systematic reviews29,30 reported very few SAEs; however, some authors have commented that vigilance about potential SAEs is required in the absence of standard FMT protocols.29,39
Table 3: Ongoing Trials of Fecal Microbiota Transplantation in Adults With Irritable Bowel Disease
|Study Number; Type||Location||Status||Disease||n||Route of Administration||Follow-up|
|NCT02390726; RCT||US||Not yet recruiting||UC||20||NR||2 years|
|NCT02417974; RCT||US||Not yet recruiting||Prevention of CD recurrence after intestinal resection||44||Colonoscopy||6 months|
|NCT02335281; RCT||China||Recruiting||IBD (UC and CD)||40||NJ tube x 1 dose||1 year|
label cohort feasibility study
|Canada||Recruiting||Active CD||20||Colonoscopy weeks 0, 4, and 8 + enema
weeks 2 and 6
|NCT01896635; RCT||Australia||Ongoing – not recruiting||UC||80||NR||8 weeks|
CD = Crohn’s disease; FMT = fecal microbiota transplantation; IBD = inflammatory bowel disease; NJ = nasojejunal; NR = not reported; RCT = randomized controlled trial; UC = ulcerative colitis.
In one RCT,28 SAEs were reported in three (8%) patients in the FMT group and two (5%) patients in the control group. In the FMT group the three AEs included one patient with worsening abdominal discomfort who tested positive for C. difficile toxin after study exit and two patients who developed patchy inflammation of the colon and rectal abscess formation.
In the control group, the two affected included one patient who required a colectomy at three weeks for worsening colitis and one patient with patchy inflammation of the colon and rectal abscess formation.
In the other study,37 two patients in each group suffered SAEs including cytomegalovirus infection (a patient in the control group), severe Crohn’s disease, abdominal pain resulting in hospital admission, and cancer of the cervix (the study group was not reported for these three events).
Mild AEs during or shortly after treatment were reported in 78% of the intervention patients and 64% of the control patients (P = 0.28) in one study.37 AEs reported by more than one patient included transient borborygmus (active bowel sounds), increase in stool frequency, vomiting after fecal infusion, transient fever, and nausea.
Administration and Cost
No standardized process for FMT is universally accepted or utilized.6,40 FMT material is medically classified as human tissue and is obtained from healthy anonymous donors or from patient-recruited family members or friends.7 There is no consensus as to the ideal donor, but currently donors undergo extensive screening via questionnaire (primarily aimed to identify high-risk behaviour), blood testing for diseases such as hepatitis and HIV, and fecal testing to rule out pathological infections such as C. difficile and Giardia.6,7,27
In a protocol used in some studies of FMT, stool is delivered for processing within several hours of collection and about 50 grams is mixed with 250 mL to 300 mL of water or saline, homogenized with a blender to achieve a liquid slurry, and filtered to remove particulate matter.7,13,28 The product is then delivered to the recipient’s bowel via an upper gastrointestinal route (e.g., nasogastric tube) or a lower gastrointestinal route (enema or colonoscopy). The efficacy of FMT may be increased with the lower route over the upper route,7,27 although some sources maintain the efficacy is equal.9
Both fresh (within six to eight hours) and frozen products are used and oral capsules are becoming an option,7,27,41 as are synthetic forms of FMT.42 The advantages of a frozen product include the ability to shift from using individual donors selected for each patient to screened volunteer donors (as with blood donations), and to the banking of frozen processed material that is ready to use when needed.39 Canadian researchers have formulated a stool substitute preparation, “RePOOPulate,” a human probiotic from purified intestinal bacterial cultures of a healthy human donor, primarily for use for C. difficile infections.6
No economic analyses of FMT for IBD were identified. A 2013 report described the processing procedures and costs at one US academic centre.40 The cost per screened donor was US$441 including laboratory analysis of donor blood and stool, and the up-front cost of reusable processing materials (blender, filter, and scale) was about US$600. Processing time per sample was 80 minutes to 110 minutes. Obtaining regulatory approval to acquire the processed fecal matter, through the clinical trials access route, takes additional time.
OpenBiome, a US non-profit organization, is devoted to making FMT easier, cheaper, safer, and more widely available by supplying hospitals with screened, filtered, and frozen material ready for clinical use.43 The cost per unit is US$635 (US$385 for the unit and US$250 for shipping and handling; the latter is waived for orders of 15 units or more). If stored correctly at –20°C, a specimen has a six-month shelf life. OpenBiome recruits healthy donors who must pass a 109-point clinical assessment; only 3% of prospective donors are accepted and OpenBiome pays US$40 per donation.44
There is growing interest in patient-tailored approaches in the treatment of IBD, but currently it is not possible to determine which patients with IBD will benefit from FMT. Innovations in microbial-based therapies include basing treatment on an individual’s particular intestinal microbiota profile to reduce pro-inflammatory species while also increasing the number or function of anti-inflammatory species, and the development of new biological drugs made in living cell lines.11
Rate of Technology Diffusion
The success of FMT in treating C. difficile infection has raised the possibility of its use in IBD; however, regulation by Health Canada and the US FDA currently limits exploration of FMT for this indication to clinical trials. Despite this, a recent article noted that at least 80 clinics in the US are offering this treatment (medical conditions not specified).19
The possibility of a microbiological basis for conditions such as irritable bowel syndrome, obesity, metabolic disease, diabetes mellitus, and neurological diseases such as multiple sclerosis, Parkinson’s disease, and chronic fatigue syndrome has been considered.7,13 There is also interest in FMT for autoimmune diseases such as rheumatoid arthritis, allergic disorders (atopy and asthma), idiopathic thrombocytopenic purpura, and various cancers.45 Good evidence of the effectiveness of FMT for these conditions is still lacking.
Several researchers have surveyed patients with IBD to gauge their interest in this treatment, and responses have generally been positive.46,47 However, there is no consensus as to the ideal protocol for FMT — including patients most likely to respond, product preparation and storage, and the route and frequency of administration.7-9,12,22,28,48-51 For example, some IBD centres carry out bowel lavage before donor feces administration and also give antibiotics before FMT to facilitate the colonization of microbiota from the donor; however, it is not clear whether these steps are necessary.27,28,39
There are advantages and disadvantages to each route of delivery.12 FMT via nasogastric tube is minimally invasive and relatively low cost, but there is a risk of vomiting and aspiration. Gastroscopy may overcome some of these problems but it is invasive, requires sedation, and is a highercost procedure. Colonoscopy is more appealing to patients and enables evaluation of the lower digestive tract, but it requires sedation, has a risk of complications, and is also a higher-cost intervention.
There is also a concern that FMT’s short-term benefits may not extend to the long term, as the adult microbiome is a highly stable structure resilient to short-term interventions and the patient may revert to the pre-treatment state once FMT treatment is completed.1
- Berg D, Clemente JC, Colombel JF. Can inflammatory bowel disease be permanently treated with short-term interventions on the microbiome? Expert Rev Gastroenterol Hepatol. 2015 Jun;9(6):781-95.
- Bernstein CN, Fried M, Krabshuis JH, Cohen H, Eliakim R, Fedail S, et al. World Gastroenterology Organization Practice Guidelines for the diagnosis and management of IBD in 2010. Inflamm Bowel Dis. 2010 Jan [cited 2015 Jun 25];16(1):112-24.
- Mosli M, Al Beshir M, Al-Judaibi B, Al-Ameel T, Saleem A, Bessissow T, et al. Advances in the diagnosis and management of inflammatory bowel disease: challenges and uncertainties. Saudi J Gastroenterol [Internet]. 2014 Mar [cited 2015 Jun 11];20(2):81-101. Available from: http://www.saudijgastro.com/temp/SaudiJGastroenterol20281-3122307_084023.pdf
- Rowe WA. Inflammatory bowel disease [Internet]. New York: Medscape. Practice Essentials; 2015 Jan 7 [cited 2015 Sep 16]. Available from: http://emedicine.medscape.com/article/179037-overview
- Goto Y, Kurashima Y, Kiyono H. The gut microbiota and inflammatory bowel disease. Curr Opin Rheumatol. 2015 Jul;27(4):388-96.
- Lee WJ, Lattimer LDN, Stephen S, Borum ML, Doman DB. Fecal microbiota transplantation: A review of emerging indications beyond relapsing Clostridium difficile toxin colitis. Gastroenterology and Hepatology. 2015;11(1):24-32.
- Borody TJ, Paramsothy S, Agrawal G. Fecal microbiota transplantation: Indications, methods, evidence, and future directions. Curr Gastroenterol Rep [Internet]. 2013 [cited 2015 Jun 10];15(8):337. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742951/pdf/11894_2013_Article_337.pdf
- Cammarota G, Ianiro G, Cianci R, Bibbo S, Gasbarrini A, Curro D. The involvement of gut microbiota in inflammatory bowel disease pathogenesis: potential for therapy. Pharmacol Ther. 2015 May;149:191-212, 2015 May.:-212.
- Merenstein D, El-Nachef N, Lynch SV. Fecal microbial therapy: promises and pitfalls. J Pediatr Gastroenterol Nutr. 2014 Aug;59(2):157-61.
- Aroniadis OC, Brandt LJ. Intestinal microbiota and the efficacy of fecal microbiota transplantation in gastrointestinal disease. Gastroenterology and Hepatology [Internet]. 2014 [cited 2015 Jun 10];10(4):230-7. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073534/pdf/GH-10-230.pdf
- Hansen JJ, Sartor RB. Therapeutic Manipulation of the Microbiome in IBD: Current Results and Future Approaches. Curr Treat Options Gastroenterol. 2015 Mar;13(1):105-20.
- Konturek PC, Haziri D, Brzozowski T, Hess T, Heyman S, Kwiecien S, et al. Emerging role of fecal microbiota therapy in the treatment of gastrointestinal and extra-gastrointestinal diseases. J Physiol Pharmacol. 2015 Aug;66(4):483-91.
- Cammarota G, Ianiro G, Bibbo S, Gasbarrini A. Fecal microbiota transplantation: a new old kid on the block for the management of gut microbiota-related disease. J Clin Gastroenterol. 2014 Nov;48 Suppl 1:S80-S84.
- Faecal microbiota transplant for recurrent Clostridium difficile infection [Internet]. London (England): NICE; 2014. [cited 2015 Jun 25]. (NICE interventional procedure guidance 485). Available from: https://www.nice.org.uk/guidance/ipg485/resources/guidance-faecal-microbiota-transplant-for-recurrent-clostridium-difficile-infection-pdf
- Faecal microbiota transplantation. Drug Ther Bull. 2014;52(12):141-4.
- Grinspan AM, Kelly CR. Fecal Microbiota Transplantation for Ulcerative Colitis: Not Just Yet. Gastroenterology. 2015 May 27.
- Guidance document: regulation of fecal microbiota therapy for the treatment of C.difficile infections [Internet]. Ottawa (ON): Health Canada; 2015 Mar 27. [cited 2015 Jun 25]. Available from: http://www.hc-sc.gc.ca/dhp-mps/consultation/biolog/fecal_microbiota-bacterio_fecale-eng.php
- Guidance for industry: enforcement policy regarding investigational new drug requirements for use of fecal microbiota for transplantation to treat Clostridium difficile infection not responsive to standard therapies [Internet]. Rockville (MD): U.S. Department of Health and Human Servies, Food and Drug Administration; 2014. [cited 2015 Jun 25]. Available from: http://www.fda.gov/BiologicsBloodVaccines/GuidanceComplianceRegulatoryInformation/Guidances/Vaccines/ucm387023.htm
- Hamzelou J. Don't give me that crap. New Scientist. 2015;225(3008):8-9.
- Kelly CR, Kahn S, Kashyap P, Laine L, Rubin D, Atreja A, et al. Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook. Gastroenterology. 2015 May 15.
- The Impact of inflammatory bowel disease in Canada: 2012 final report and recommendations [Internet]. Toronto (ON): Crohn's and Colitis Foundation of Canada; 2012. [cited 2015 Jun 25]. Available from: http://www.isupportibd.ca/pdf/ccfc-ibd-impact-report-2012.pdf
- Ianiro G, Bibbo S, Scaldaferri F, Gasbarrini A, Cammarota G. Fecal microbiota transplantation in inflammatory bowel disease: Beyond the excitement. Medicine (United States). 2014;93(19):e97.
- Ananthakrishnan AN. Environmental risk factors for inflammatory bowel disease. Gastroenterol Hepatol (N Y) [Internet]. 2013 Jun [cited 2015 Sep 16];9(6):367-74. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736793
- Nguyen GC, Devlin SM, Afif W, Bressler B, Gruchy SE, Kaplan GG, et al. Defining quality indicators for best-practice management of inflammatory bowel disease in Canada. Can J Gastroenterol Hepatol. 2014 May [cited 2015 Jun 25];28(5):275-85. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049258
- D'Haens GR, Sartor RB, Silverberg MS, Petersson J, Rutgeerts P. Future directions in inflammatory bowel disease management. J Crohns Colitis. 2014 Aug 1;8(8):726-34.
- Lautenschlager C, Schmidt C, Fischer D, Stallmach A. State of the art: Therapeutical strategies for the treatment of inflammatory bowel disease. Current Drug Therapy. 2013;8(2):99-120.
- Allegretti JR, Hamilton MJ. Restoring the gut microbiome for the treatment of inflammatory bowel diseases. World J Gastroenterol [Internet]. 2014 Apr 7 [cited 2015 Jun 11];20(13):3468-74. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974513/pdf/WJG-20-3468.pdf
- Moayyedi P, Surette MG, Kim PT, Libertucci J, Wolfe M, Onischi C, et al. Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial. Gastroenterology. 2015 Apr 7.
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Author: Vicki Foerster
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Cite as: Fecal microbiota transplantation (fecal transplant) for adults with inflammatory bowel disease. Ottawa: CADTH; 2015 Oct. (CADTH issues in emerging health technologies; issue 143)
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