Gabapentin for HIV-associated Neuropathic Pain: A Review of the Clinical Effectiveness

( Last Updated : January 22, 2016)
Project Line:
Health Technology Review
Project Sub Line:
Summary with Critical Appraisal
Project Number:



  1. What is the clinical effectiveness of gabapentin for the treatment of HIV-associated neuropathic pain?

Key Message

There is limited evidence for the use of gabapentin for the treatment of HIV-associated neuropathy. One relevant RCT, included in a systematic review, and one non-randomized study were identified. The studies suggest that gabapentin may improve pain and related sleep disturbances caused by HIV-associated sensory neuropathy; however, due to the limitations of the evidence, the effectiveness of gabapentin for patients with HIV-associated neuropathy is inconclusive.