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High Dose Stimulants for Attention-Deficit/Hyperactivity Disorder: Clinical Effectiveness, Safety, and Guidelines

Last updated: January 29, 2015
Project Number: RA0728-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Reference List
Result type: Report


  1. What is the effectiveness and safety of high dose stimulants in children and adolescents (six to18 years) with Attention Deficit Hyperactivity Disorder (ADHD)?
  2. What is the comparative effectiveness and safety of high dose stimulants in adults (>18 years) with ADHD?
  3. What are the evidence-based guidelines regarding the use of high dose stimulants in patients with ADHD?

Key Message

One systematic review, three randomized-controlled trials, and four non-randomized studies were identified regarding high dose stimulants for Attention Deficit Hyperactivity Disorder.