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Irreversible Electroporation for Tumors of the Pancreas or Liver: Review of Clinical and Cost-Effectiveness

Last updated: February 10, 2016
Project Number: RC0748-000
Product Line: Rapid Response
Research Type: Devices and Systems
Report Type: Summary with Critical Appraisal
Result type: Report

Question

  1. What is the clinical effectiveness and safety of irreversible electroporation (IRE) in patients with tumors of the pancreas or liver?
  2. What is the cost-effectiveness of irreversible electroporation (IRE) in patients with tumors of the pancreas or liver?

Key Message

Irreversible electroporation appears to be feasible and safe for patients with tumors of the pancreas or liver. The percutaneous approach seems to result in fewer adverse events. IRE may be effective in increasing overall and progression free survival in patients with unresectable tumors of the pancreas or liver, however, the conclusions are based on studies without a control group. Further research is needed in order to make definite conclusions.