CADTH is committed to supporting Canada’s health care decision-makers through this challenging and uncertain time.
For evidence, tools, and resources related to COVID-19, visit our COVID-19 Evidence Portal.


Begin main content

Long-term Nabilone Use: A Review of the Clinical Effectiveness and Safety

Last updated: October 16, 2015
Project Number: RC0715-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Summary with Critical Appraisal
Result type: Report


  1. What is the clinical effectiveness of long-term nabilone use?
  2. What is the evidence for the safety and harms of long-term nabilone use?

Key Message

Based upon one systematic review and four RCTs, nabilone was more effective than placebo in improving PTSD-associated nightmares and quality of life, neuropathic pain related to MS and diabetes, and spasticity due to spinal cord injury for four to nine weeks of treatment. Adverse events were generally not considered serious. However, the generalizability of these results is uncertain given the limited number of participants in each trial.