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Magnetic seed localization for soft tissue lesions in breast patients: Clinical effectiveness, cost-effectiveness, and guidelines

Last updated: May 23, 2019
Project Number: RC1122-000
Product Line: Rapid Response
Research Type: Devices and Systems
Report Type: Summary with Critical Appraisal
Result type: Report

Question

  1. What is the clinical effectiveness of magnetic seed localization for non-palpable breast lesions in breast surgery patients?
  2. What is the cost-effectiveness of magnetic seed localization for non-palpable breast lesions in breast surgery patients?
  3. What are the evidence based guidelines regarding the use of magnetic seed localization for non-palpable breast lesions in breast surgery patients?

Key Message

Five primary studies were identified for the use of magnetic seeds for localization of non-palpable breast lesions in breast cancer patients; however, these studies were all single-arm non-randomized trials with less than 200 patients, some fewer than 50. This makes it difficult to determine how this technique compares to the current standard for effectiveness and safety. Overall, the studies suggest this technique is effective and safe with surgeons indicating they are satisfied and able to adopt this technique.No cost-effectiveness studies and evidence-based guidelines were identified for the use of magnetic seed localization for non-palpable breast lesions in breast surgery patients; therefore, no conclusion can be made on the comparative cost on the use of magnetic seed localization. With a paucity of evidence and all identified studies having methodological flaws, the effectiveness, safety and the use of magnetic seeds for localization of non-palpable breast lesions in breast cancer patients remains uncertain. Additionally, all studies identified were conducted outside of Canada which may not inform Canadian policy and decision makers on the use of this technique in the Canadian population.