New at CADTH - April 2020

News and Events

CADTH is committed to serving you during the COVID-19 crisis. If you’re looking for credible answers to your COVID-19 questions, CADTH can help. We have created a website where you’ll find information from CADTH and other respected organizations related to COVID-19. As the COVID-19 situation is changing daily, we’ll be updating this site regularly as new evidence becomes available.

After carefully considering the evolving situation with COVID-19, and keeping in mind the Public Health Agency of Canada’s advice on mass gatherings during the outbreak, we’ve made the difficult decision to cancel our in-person conference, the CADTH Symposium, scheduled to be held in Toronto from April 18 to 21, 2020. For more information on the cancellation please visit the Symposium website.

CADTH continues to support health care decision-makers throughout this challenging period. We have successfully shifted to a virtual office and have the tools in place to continue delivering our programs and services. We continue to monitor our operations to identify potential disruptions to our core business activities and we will promptly notify our stakeholders if we anticipate delays. To help answer some common questions our stakeholders may have, we have developed a Q&A section on our CDR page and our pCODR page. Should you have additional questions, contact us.

Drug Reimbursement Recommendations

CADTH recently issued the following CADTH Canadian Drug Expert Committee (CDEC) drug reimbursement recommendations:

• sodium zirconium cyclosilicate (Lokelma) for hyperkalemia
• safinamide (Onstryv) for Parkinson disease
• iron (III) isomaltose 1000 (Monoferric) for iron deficiency anemia
• ixekizumab (Taltz) for ankylosing spondylitis.

CADTH recently issued the following CADTH pan-Canadian Oncology Drug Review (pCODR) Expert Review Committee (pERC) drug reimbursement recommendation:

• Daratumumab (Darzalex) for multiple myeloma.

CADTH Reports

CADTH recently completed the following reports:

Horizon Scan

• Horizon Scan Roundup — 2019 – Report

Environmental Scan

• The Use of Real-World Evidence for Medical Device Assessment: An Environmental Scan – Report

Issues in Emerging Health Technologies

• Early Identification of Ischemic Stroke – Report
• Small Molecule Calcitonin Gene-Related Peptide Receptor Antagonists for the Acute Treatment of Migraine – Report
• Lasmiditan for the Acute Treatment of Migraine – Report
• Endobronchial Valves for the Treatment of Severe Emphysema – Report

Rapid Response Reports — Drug

• Rituximab for Pediatric Patients With Primary Membranous Nephropathy: Clinical Effectiveness and Cost-Effectiveness – Reference List
• Community Water Fluoridation Programs: Clinical Effectiveness and Safety – Reference List
• Normal Saline for Sepsis Management: Clinical Effectiveness – Summary of Abstracts
• Lipids and Related Supplements for Mild Traumatic Brain Injury: Clinical Effectiveness – Summary of Abstracts
• Nutritional Supplements for Mild Traumatic Brain Injury: Clinical Effectiveness – Summary of Abstracts
• Vitamin D Supplementation for the Prevention of Tuberculosis Infection: Clinical Effectiveness and Guidelines – Summary of Abstracts
• Sedative Agents During Medical Procedures: Guidelines – Summary of Abstracts
• Oral Rehydration Solutions Versus Drink of Choice in Children With Dehydration: A Review of Clinical Effectiveness – Summary With Critical Appraisal
• Propranolol for Post-Traumatic Stress Disorder: A Review of Clinical Effectiveness – Summary With Critical Appraisal

Rapid Response Reports — Medical Devices and Systems

• Islet Cell Transplantation for Patients With Unstable or Uncontrollable Diabetes Mellitus: Clinical Effectiveness, Cost-Effectiveness and Guidelines – Reference List
• Nasal Decolonization for the Prevention of Surgical Site Infections: Clinical Effectiveness, Cost-Effectiveness, and Guidelines – Reference List
• Disposable Handheld Vaporization Devices for Inhalation of Medical Cannabis: Clinical Effectiveness and Cost-Effectiveness – Reference List
• Composite Resin Versus Amalgam for Dental Restorations: Clinical Effectiveness and Safety – Reference List
• Masks During Aerosol Generating Dental Procedures: Clinical Effectiveness and Guidelines – Reference List
• Masks During Aerosol Generating ENT Procedures: Clinical Effectiveness and Guidelines – Reference List
• Hand Washing for Patients: Clinical Effectiveness and Guidelines – Summary of Abstracts
• Intravenous Catheter Sizes for Fluid Resuscitation: Clinical Effectiveness and Guidelines – Summary of Abstracts
• Timely Treatment and Diagnosis of Adult Concussions: Clinical Effectiveness and Guidelines – Summary of Abstracts
• Pain Management Programs for Pediatric Patients With Chronic Pain Conditions: Clinical Effectiveness, Cost Effectiveness, and Guidelines – Summary of Abstracts
• Negative Pressure Wound Therapy for Patients Post-Surgery: Clinical Effectiveness, Cost- Effectiveness, and Guidelines – Summary of Abstracts
• Intravenous Push Injections in Adults: Safety and Guidelines – Summary of Abstracts
• Sodium Chloride Impregnated Gauze for Fungating, Malignant Wounds: Clinical Effectiveness, Cost-Effectiveness, and Guidelines – Summary of Abstracts
• Brachytherapy Administration for Cervical and Vaginal Cancer: Safety and Guidelines – Summary of Abstracts
• Shared Smoking Devices and the Transmission of Tuberculosis: Clinical Evidence – Summary of Abstracts
• Troponin I Point of Care Testing for Patients With Suspected Acute Coronary Syndrome or Myocardial Infarction: Clinical Utility, Cost-Effectiveness and Guidelines – Summary of Abstracts
• Direct Anterior Approach for Total Hip Arthroplasty: Guidelines – Summary of Abstracts
• Hand Washing for Health Care Workers to Reduce the Transmission of Infection: Clinical Effectiveness and Guidelines – Summary of Abstracts
• Treatment of Tuberculosis: A Review of Guidelines – Summary With Critical Appraisal
• Tuberculosis in People With Compromised Immunity: A Review of Guidelines – Summary With Critical Appraisal
• Drug-Resistant Tuberculosis: A Review of the Guidelines – Summary With Critical Appraisal
• Assessment of Dehydration and Oral Rehydration Therapy for Pediatric Patients with Dehydration: A Review of Clinical Effectiveness, Clinical Utility, and Guidelines – Summary With Critical Appraisal
• Experiences With and Expectations of Robotic Surgical Systems: A Rapid Qualitative Review – Summary With Critical Appraisal
• Masks for Prevention of Influenza Transmission in Acute and Long-Term Care Settings: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines – Summary With Critical Appraisal
• Serial X-Ray Radiography for the Diagnosis of Osteomyelitis: A Review of Diagnostic Accuracy, Clinical Utility, Cost-Effectiveness, and Guidelines – Summary With Critical Appraisal
• Intravitreal Dexamethasone Implants for Non-infectious Uveitis: A Review of Clinical Effectiveness, Cost-effectiveness, and Guidelines – Summary With Critical Appraisal
• Body Weight Modification Interventions for Chronic Non-Cancer Pain: A Review of Clinical Effectiveness – Summary With Critical Appraisal

Rapid Response Reports — Other Diagnostics

• Orthotic Bracing or Splinting of the Lower Extremities and Spine in Patients with Chronic, Non-Cancer Pain: Clinical Effectiveness and Guidelines – Reference List
• Circulating Tumour DNA Testing for the Identification of Genetic Mutations: Diagnostic Test Accuracy and Clinical Utility – Reference List
• Sleep Interventions for Chronic, Non-Cancer Pain: Clinical Effectiveness and Guidelines – Reference List
• Artificial Intelligence for Classification of Lung Nodules: A Review of Clinical Utility, Diagnostic Accuracy, Cost-Effectiveness, and Guidelines – Summary With Critical Appraisal
• Intraosseous Contrast Media Injection for Computed Tomography Scan or Magnetic Resonance Imaging: A Review of Clinical Effectiveness and Guidelines – Summary With Critical Appraisal
• Management of Patients Presenting With Pneumonia in the Emergency Department: Guidelines – Summary of Abstracts

Other Tools

• Palivizumab In Brief (cadth.ca/tools/brief-palivizumab-infection-prevention-inuit-infants-review)
• Digital Health evidence bundle (cadth.ca/digital-health)

Tell Us What You Think

We love hearing how our products and services are influencing health care policies, clinical practices, and patient outcomes. If you have a success story to share, please get in touch with your CADTH Liaison Officer.

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