New at CADTH — May 2019

News and Events

Thank you to everyone who attended the 2019 CADTH Symposium in Edmonton. Presentations from the CADTH Symposium are now available online, as are photos from the event. Be sure to take a moment to re-enjoy the three days

Drug Reimbursement Recommendations

CADTH recently issued the following CADTH Canadian Drug Expert Committee drug reimbursement recommendations:

• crisaborole (Eucrisa) for atopic dermatitis.

CADTH recently issued the following CADTH pan-Canadian Oncology Drug Review (pCODR) Expert Review Committee (pERC) Drug Reimbursement Recommendations:

• pralatrexate (Folotyn) for peripheral t-cell lymphoma (PTCL)
• blinatumomab (Blincyto) for Philadelphia chromosome positive (Ph+) B-cell precursor acute lymphoblastic leukemia (ALL)
• enzalutamide (Xtandi) for non-metastatic castration-resistant prostate cancer
• dinutuximab (Unituxin) for neuroblastoma.

CADTH Reports

CADTH recently completed the following reports:

Horizon Scans

• An Overview of Clinical Applications of 3D Printing and Bioprinting
• Esketamine for Treatment-Resistant Depression

Rapid Response Reports — Drug

• Botulinum Toxin for Raynaud’s Disease: Clinical Effectiveness — Summary of Abstracts
• Non-Insulin Therapies Versus Prandial Insulin for Adults with Type 2 Diabetes: Clinical Effectiveness, Cost-Effectiveness, and Guidelines — Summary of Abstracts
• Normal Saline versus Ringer’s Lactate for Patients with Traumatic Injury: Comparative Clinical Effectiveness — Summary of Abstracts
• Buprenorphine for Opioid Use Disorder: A Review of Comparative Clinical Effectiveness, Safety, Cost-Effectiveness, and Guidelines — Summary with Critical Appraisal
• Fluoroquinolones for the Treatment of Intra-Abdominal Infections: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines — Summary with Critical Appraisal
• Fluoroquinolones for the Treatment of Otitis Media: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines — Summary with Critical Appraisal
• Prescription Monitoring Programs for Optimizing Medication Use and Preventing Harm: A Review of Safety and Guidelines — Summary with Critical Appraisal
• Fluoroquinolones for the Treatment of Urinary Tract Infection: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines — Summary with Critical Appraisal
• Buprenorphine for Opioid Use Disorders: A Rapid Qualitative Review — Summary with Critical Appraisal
• Vitamin D Supplementation for the Prevention of Falls and Fractures in Residents of Long-Term Care Facilities: A Review of Clinical Effectiveness,Cost-Effectiveness, and Guidelines — Summary with Critical Appraisal
• Biologics versus Immunomodulators or Antibiotics for the Management of Fistulizing Crohn’s Disease: A Review of Comparative Clinical Effectiveness and Cost-Effectiveness — Summary with Critical Appraisal

Rapid Response Reports — Medical Devices and Systems

• Frequency of Eye Examinations: Guidelines — Reference List
• Tomography in Eye Examinations: Guidelines — Reference List
• Fundus Photography in Eye Examinations: Guidelines — Reference List
• Automated Perimetry or Electroretinography for Visual Field Testing in Eye Examinations: Guideline — Reference List
• Fidaxomicin Pulse Therapy for Clostridium Difficile Infection: Clinical Effectiveness — Reference List
• eConsult for Patients Requiring Specialist Consultation: Clinical Effectiveness, Cost-Effectiveness, and Guidelines — Reference List
• Remote Monitoring for Chronic Cardiac Conditions: Clinical Effectiveness and Cost-Effectiveness — Reference List
• Non-Invasive Brain Stimulation Techniques for the Treatment of the Behavioural and Psychological Symptoms of Severe Dementia: Clinical Effectiveness — Reference List
• Remote Monitoring for Non-Cardiac Chronic Conditions: Clinical Effectiveness and Cost-Effectiveness— Reference List
• Occult Blood Detection Testing for Non-Colorectal Cancer Related Medical Conditions: Clinical Effectiveness — Reference List
• Preoperative Seed Placement for Breast Cancer Surgery: Clinical Effectiveness, Cost-Effectiveness, and Guidelines — Summary of Abstracts
• Infrared Tympanic Thermometers for Measurement of Temperature in Adults and Children: Clinical Effectiveness, Diagnostic Accuracy, and Guidelines — Summary of Abstracts
• Non-Pharmacological Interventions for the Treatment of Behavioural Issues: Clinical Effectiveness, Cost-Effectiveness, and Guidelines — Summary of Abstracts
• Coated Catheters to Reduce Urinary Tract Infections: Clinical Effectiveness, Cost-Effectiveness, and Guidelines — Summary of Abstracts
• Tetrasodium Ethylenediaminetetraacetic Acid for Locking Central Venous Access Devices: Clinical Effectiveness, Cost-Effectiveness, and Guidelines — Summary of Abstracts
• Hand Hygiene and Glove Use in Dental Settings: Clinical Effectiveness, Cost-Effectiveness, and Guidelines — Summary of Abstracts
• Bacteriophage Therapy for Multi-Drug Resistant Bacterial Infections: Clinical Effectiveness and Guidelines — Summary of Abstracts
• Urinary Dipstick Testing for Bladder Cancer Screening: Diagnostic Accuracy, Clinical Effectiveness and Guidelines — Summary of Abstracts
• Blunt Needles for Withdrawing from Multi-dose Vials: Safety and Guidelines — Summary of Abstracts
• Showering to Prevent Lyme Disease: Clinical Effectiveness and Guidelines — Summary of Abstracts
• Non-Manual Ultraviolet Light Disinfection for Hospital Acquired Infections: A Review of Clinical Effectiveness and Guidelines — Summary with Critical Appraisal
• Gene Expression Profiling Tests for Breast Cancer: A Rapid Qualitative Review — Summary with Critical Appraisal
• Intraoperative Mammography for Breast Cancer Surgery: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines — Summary with Critical Appraisal
• Sentinel Lymph Node Biopsy for the Management of Breast Cancer: A Review of Guidelines — Summary with Critical Appraisal

Other Tools

• In Brief: Standard-Duration Versus Extended-Duration Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention: A Review
• Evidence Highlights: Community Water Fluoridation Programs
• Infographic: Publicly Funded and Managed Naloxone Programs in Canada (Updated April 2019)

Tell Us What You Think

We love hearing how our products and services are influencing health care policies, clinical practices, and patient outcomes. If you have a success story to share, please get in touch with your CADTH Liaison Officer.

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