Begin main content

Non-Invasive Serum Markers for the Diagnosis and Monitoring of Liver Fibrosis: Diagnostic Accuracy, Clinical Effectiveness/Utility, Cost-Effectiveness, and Guidelines

Last updated: August 15, 2017
Project Number: RA0924-000
Product Line: Rapid Response
Research Type: Devices and Systems
Report Type: Reference List
Result type: Report

Question

  1. What is the diagnostic accuracy of non-invasive serum markers to detect liver fibrosis in patients with or suspected of having liver disease?
  2. What is the clinical effectiveness and clinical utility of non-invasive serum markers to detect liver fibrosis in patients with or suspected of having liver disease?
  3. What is the cost-effectiveness of non-invasive serum markers to detect liver fibrosis in patients with or suspected of having liver disease?
  4. What are the evidence-based guidelines associated with the use of non-invasive serum markers to detect liver fibrosis in patients with or suspected of having liver disease?

Key Message

Four systematic reviews (three including meta-analyses), two meta-analyses, three randomized controlled trials, and 36 non-randomized studies were identified regarding non-invasive serum markers for the diagnosis and monitoring of liver fibrosis. Additionally, eight evidence-based guidelines were identified.