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Point-of-care versus Central Laboratory Troponin Testing for Diagnosis of Acute Coronary Syndrome in Acute Care Settings: A Review of the Clinical and Economic Evidence

Last updated: October 18, 2012
Project Number: RC0396-000
Product Line: Rapid Response
Report Type: Summary with Critical Appraisal
Result type: Report

Question

1. For patients with suspected acute coronary syndrome (ACS) in acute care settings, what is the diagnostic test performance of:

  • central laboratory troponin T compared with point-of-care troponin T assays?
  • central laboratory troponin I compared with point-of-care troponin I assays?

 

2. For patients with suspected ACS in acute care settings, what is the comparative clinical effectiveness of:

  • central laboratory troponin T compared with point-of-care troponin T assays?
  • central laboratory troponin I compared with point-of-care troponin I assays?

 

3. For patients with suspected ACS in acute care settings, what is the cost-effectiveness of:

  • central laboratory troponin T compared with point-of-care troponin T assays?
  • central laboratory troponin I compared with point-of-care troponin I assays?

Key Message

POC troponin I testing decreased the length of stay in the emergency department compared to central laboratory troponin I testing. Central laboratory troponin testing was found have better diagnostic accuracy than conventional POC troponin assays. However, POC troponin assay results correlated well with the results of central laboratory troponin assays.