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Rapid and Simultaneous Tuberculosis and Antibiotic Susceptibility Testing for the Diagnosis of Pulmonary Tuberculosis and Rifampicin Resistance: Diagnostic Accuracy and Cost-Effectiveness

Last updated: June 29, 2020
Project Number: RB1499-000
Product Line: Rapid Response
Research Type: Other Diagnostics
Report Type: Summary of Abstracts
Result type: Report

Question

  1. What is the diagnostic accuracy of rapid and simultaneous tuberculosis and antibiotic susceptibility testing for the detection of pulmonary tuberculosis compared to smear microscopy?
  2. What is the diagnostic accuracy of rapid and simultaneous tuberculosis and antibiotic susceptibility testing for the detection of pulmonary tuberculosis compared to mycobacterial cultures?
  3. What is the diagnostic accuracy of rapid and simultaneous tuberculosis and antibiotic susceptibility testing for the detection of rifampicin resistance compared to culture-based drug susceptibility testing?
  4. What is the cost-effectiveness of rapid and simultaneous tuberculosis and antibiotic susceptibility testing for the detection of pulmonary tuberculosis or rifampicin resistance?

Key Message

Three systematic reviews with meta-analysis were identified regarding the diagnostic accuracy of rapid and simultaneous tuberculosis and antibiotic susceptibility testing for the detection of pulmonary tuberculosis compared to mycobacterial cultures and rifampicin resistance compared to culture-based drug susceptibility testing. Authors of one of the three systematic reviews with meta-analysis also compared the diagnostic accuracy of rapid and simultaneous tuberculosis and antibiotic susceptibility testing for the detection of pulmonary tuberculosis compared to smear microscopy. In addition, four economic evaluations were identified regarding the cost-effectiveness of rapid and simultaneous tuberculosis and antibiotic susceptibility testing for the detection of pulmonary tuberculosis or rifampicin resistance.