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An Overview of Clinical Applications of Artificial Intelligence

Published on: October 1, 2018
Result type: Reports
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Background Like many industries, health care is generating increased volumes of data and becoming increasingly reliant on it.1 Applications that use artificial intelligence (AI) may offer opportunities to make better use of health care’s increasingly data-driven environment and could change the way health care is delivered to Canadians. What is ...

  • Project Number: EH0070-000

Monoclonal Antibodies for Osteoarthritis of the Hip or Knee

Published on: July 11, 2018
Result type: Reports
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Osteoarthritis (OA) is a common and chronic disease of the synovial joints caused by biomechanical factors, inflammation, and joint tissue damage. The current therapeutic options include non-pharmacologic therapy and topical analgesics, followed by oral analgesics and injectable agents, followed by surgery for end-stage disease. OA typically ...

  • Project Number: EH0069-000

Tags

Hip, Knee, Nerve Growth Factor, Osteoarthritis, Pain Management, Musculoskeletal, Pain management, Knee, Hip, anti-NGF, fasinumab, fulranumab, tanezumab

New Technologies for the Treatment of Peripheral Artery Disease

Published on: April 23, 2018
Result type: Reports
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Peripheral artery disease (PAD) is primarily caused by plaque in the arteries that supply blood to the body. It generally indicates systemic atherosclerosis and an increased risk for cardiovascular events. People with diabetes, those who smoke, the elderly, and those with cardiovascular disease are particularly at risk for PAD.

  • Project Number: EH0064-000

Tags

Atherectomy, Comprehensive Health Care, Diabetic Foot, Diagnosis, Diagnostic Tests, Excimer Laser, Ischemia, Leg Ulcer, Lower Extremity, Lower Limb, Mass Screening, Peripheral Arterial Disease, Ulcer, Venous Insufficiency, Diagnostic tests, Medical devices, Peripheral vascular disease, Cardiovascular:Peripheral vascular disease, Monitoring, Occlusion, Physiologic, Ulcers, ischaemia, lower extremities, lower limbs, revascularisation, revascularization

Gene Therapy: An Overview of Approved and Pipeline Technologies

Published on: March 29, 2018
Result type: Reports
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Gene therapy is an area of therapeutics aimed at curing, or significantly improving the management of, diseases with few or no treatment alternatives.

  • Project Number: EH0068-000

Tags

Cancer, Eye, Gene Therapy, Gene Transfer Techniques, Genetic Engineering, Genetics, RNA Editing, Regenerative Medicine, Cancer, Cancer, Genetics, CAR T-cells, CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, Clustered Regularly Interspaced Short Palindromic Repeats, DNA editing, Genetic Therapy, Kymriah, Luxturna, Strimvelis, Yescerta, chimeric antigen receptor, chimeric immunoreceptors, courtes répétitions palindromiques groupées et régulièrement espacées, gene editing, genetic therapy, génothérapie, human gene transfer, immunorécepteurs chimériques, lymphocytes CAR-T, médecine régénérative, médecine régénératrice, récepteur antigénique chimérique, thérapie génique, transfert de gènes humains, transfert génétique humain, voretigene neparvovec, voretigène néparvovec, édition génique, édition génomique, édition génétique

Flash Glucose Monitoring System for Diabetes

Published on: March 29, 2018
Result type: Reports
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FreeStyle Libre is a glucose monitoring system that uses a sensor implanted in the arm that a health care provider scans with a specialized reader for a record of glucose levels, trends, and patterns in people with diabetes.

  • Project Number: EH0053-000

Tags

Blood Glucose, Diabetes Mellitus, Hemoglobin A, Hemoglobinometry, Diabetes, Medical devices, Freestyle Libre, Glycosylated

A Gene Expression Test to Assess the Likelihood of Obstructive Coronary Artery Disease

Published on: March 14, 2018
Result type: Reports
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Coronary artery disease is the most common form of cardiovascular disease in Canada. A new blood test, Corus CAD, combines age, sex, and gene expression in an algorithm to determine the likelihood a person has obstructive coronary artery disease. Corus CAD is intended for use in patients with suspected undiagnosed obstructive coronary artery ...

  • Project Number: EH0061-000

Tags

Arteriosclerosis, Atherosclerosis, Coronary Artery Disease, Coronary Disease, Diagnostic Tests, Gene Expression, Genetics, Cardiovascular, Coronary artery disease, Diagnostic tests, Genetic tests, Genetics, Genetic test, blood test

Voretigene Neparvovec: An Emerging Gene Therapy for the Treatment of Inherited Blindness

Published on: March 14, 2018
Result type: Reports
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Inherited retinal dystrophies (IRDs) are a major cause of early-onset blindness. Biallelic RPE65-mediated IRD, the most severe form of IRD, occurs when there are mutations in both alleles of the RPE65 gene in retinal pigment epithelium (RPE) cells. Voretigene neparvovec, developed by Spark Therapeutics, Inc., Pennsylvania, US, is a g...

  • Project Number: EH0067-000

Tags

Amaurosis, Blindness, Eye, Genetic Engineering, Genetics, Leber Congenital Amaurosis, Optic Atrophy, Retina, Retinal, Genetics, AAV2-hRPE65v2, Congenital, Genetic Therapy, Hereditary, Hereditary, Leber, Leber congenital amaurosis type 2, Luxturna, RPE65, blind

A Noncultured Autologous Skin Cell Spray Graft for the Treatment of Burns

Published on: March 13, 2018
Result type: Reports
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Burn injuries cause trauma and suffering, and can involve long hospital stays. The ReCell Autologous Cell Harvesting Device is a system that harvests, processes, and delivers an individual’s own skin cells for the treatment of burns. As it does not require cell culturing in the laboratory, the procedure takes approximately 30 minutes.

  • Project Number: EH0066-000

Tags

Cell Transplantation, Dermatology, Dermis, Keratinocytes, Skin Transplantation, Suspensions, Transplantation, Transplants, Wounds and Injuries, Dermatology, Medical devices, Wounds and injuries, Autologous, CellMist, ReCell, SkinGun, Transplant, Transplanted, aerosol, aerosolized, burned, skin grafting, skin grafts

Monoclonal antibodies to prevent migraine headaches

Published on: February 1, 2018
Result type: Reports
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Migraine is a common, chronic, neurological disorder. To prevent chronic migraine headaches, botulinum toxin has received regulatory approval. This medication requires multiple injections into specific head and neck sites. Other drugs are used in migraine prevention but patient adherence and efficacy are issues.

  • Project Number: EH0063-000

Tags

Headache, Headache Disorders, Migraine Disorders, Monoclonal Antibodies, Nervous System, Headache disorders, Nervous system, eptinezumab, erenumab, fremanezumab, galcanezumab, headaches, mAbs

Newer Drugs for Type 2 Diabetes: An Emerging Adjunctive Therapy to Insulin for Type 1 Diabetes?

Published on: January 22, 2018
Result type: Reports
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There are two major categories of diabetes. Type 1 diabetes (T1D) is characterized by severe impairment or an absolute deficiency of insulin due to autoimmune destruction of pancreatic cells. Type 2 diabetes (T2D) is characterized by a combination of insulin resistance and decreased insulin secretion. Insulin is the mainstay of treatment for ...

  • Project Number: EH0048-000

Tags

Diabetes Mellitus, Dipeptidyl-Peptidase IV Inhibitors, Glucagon-Like Peptide 1, IDDM, Sodium-Glucose Transport Proteins, Diabetes, T1D, T1DM, diabetes type 1, diabetes type one, insulin dependent diabetes mellitus, juvenile diabetes, type 1, type 1 diabetes, type 2, type one diabetes