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Early Identification of Stroke

Last Updated: January 17, 2020
Result type: Reports

Every year in Canada, there are more than 50,000 new strokes and 14,000 deaths from stroke. The first step to delivering optimal stroke care is fast and effective management in the pre-hospital environment. There are numerous opportunities for time saving in pre-hospital stroke care — from detection to triage to transportation. This Horizon Scan...

  • Project Number: EH0080-000

Magnetic Resonance-Guided Radiotherapy: MR-Simulation and MR-Linac

Last Updated: January 16, 2020
Result type: Reports

Radiotherapy is an important treatment tool used for two-thirds of people who receive cancer treatment. Magnetic resonance imaging (MRI) is being used for treatment guidance because it offers superior soft tissue contrast, which can reduce toxicity to organs at risk and to healthy tissue. Newer magnetic resonance (MR) systems — magnetic resonanc...

  • Project Number: EH0074-000

Inclisiran: A Small Interfering RNA Molecule for Treating Hypercholesterolemia

Last Updated: December 9, 2019
Result type: Reports
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Atherosclerotic cardiovascular disease (ASCVD) remains one of the leading causes of death in Canada. Cholesterol, specifically low-density lipoprotein cholesterol (LDL-C), is a major risk factor for cardiovascular disease (CVD) and is thereby targeted to reduce the likelihood of a cardiovascular event, such as a myocardial infarction (MI) and...

  • Project Number: EH0076-000

An Overview of Liquid Biopsy for Screening and Early Detection of Cancer

Last Updated: November 14, 2019
Result type: Reports
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Summary Currently, population-based cancer screening is limited to select cancers (e.g., cervical cancer). Cancer diagnoses are confirmed using tissue biopsies in solid tumours.1 However, these biopsies are invasive; associated with multiple complications;2 and are limited by the anatomical location of the tumour,3 the evolutio...

  • Project Number: EH0077-000

Dementia Villages

Last Updated: October 24, 2019
Result type: Reports

As the population ages, decision-makers are faced with different choices of care models for people diagnosed with dementia. Recent media reports have focused on dementia villages, first developed at de Hogeweyk in the Netherlands. This Horizon Scanning bulletin will present a narrative review of the literature describing elements of care, as wel...

  • Project Number: EH0071-000

Esketamine for Treatment-Resistant Depression

Last Updated: April 17, 2019
Result type: Reports
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Major depressive disorder (MDD) is a common, debilitating, and recurrent mental health disorder. Approximately 10% to 30% of patients with MDD will not reach complete clinical remission despite multiple antidepressant pharmacologic approaches — this subpopulation is described as having treatment-resistant depression (TRD). TRD is a more chall...

  • Project Number: EH0075-000

An Overview of Clinical Applications of 3-D Printing and Bioprinting

Last Updated: April 15, 2019
Result type: Reports
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In the 1980s, the first 3-D printing (3-DP) patent was filed by Charles Hull. Since then, substantial hype and growing demand has developed around a technology class that some anticipate will fundamentally change manufacturing across industries. Promising medical solutions such as bionic limbs, replacement organs, and advanced pharmaceutical ...

  • Project Number: EH0072-000

An Overview of Clinical Applications of Artificial Intelligence

Last Updated: October 1, 2018
Result type: Reports
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Like many industries, health care is generating increased volumes of data and becoming increasingly reliant on it. Applications that use artificial intelligence (AI) may offer opportunities to make better use of health care’s increasingly data-driven environment and could change the way health care is delivered to Canadians.

  • Project Number: EH0070-000

Monoclonal Antibodies for Osteoarthritis of the Hip or Knee

Last Updated: July 11, 2018
Result type: Reports
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Osteoarthritis (OA) is a common and chronic disease of the synovial joints caused by biomechanical factors, inflammation, and joint tissue damage. The current therapeutic options include non-pharmacologic therapy and topical analgesics, followed by oral analgesics and injectable agents, followed by surgery for end-stage disease. OA typically ...

  • Project Number: EH0069-000