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Leukoreduction: The techniques used, their effectiveness and costs

Last Updated: January 1, 1998
Result type: Reports

Cite as: Gibis B, Baladi JF. Leukoreduction: the techniques used, their effectiveness and costs. Ottawa: Canadian Coordinating Office for Health Technology Assessment (CCOHTA); 1998. Leukocytes, as part of transfusions, can cause a variety of side-effects such as febrile reactions, platelet refractoriness, and transmission of viruses like the c...

The Heart Laser: Transmyocardial Revascularization Treatment of Angina Pectoris

Last Updated: January 1, 1998
Result type: Reports

The Heart Laser™, a new surgical cardiac laser system, is used in the treatment of severe angina pectoris. The chest pain experienced by those with angina pectoris can be due to ischemic heart disease. Chest pain occurs when the heart muscle does not receive an adequate supply of oxygenated blood. This is often a result of cholesterol plaque ...

Herceptin: monoclonal antibody therapy for metastatic breast cancer

Last Updated: January 1, 1998
Result type: Reports

Herceptin® (Trastuzumab) anti-HER2 humanized monoclonal antibody is an intravenous injection developed by Genentech, Inc. for the treatment of metastatic breast cancer. Herceptin® inhibits cell growth by binding the Human Epidermal growth factor Receptor protein 2 (HER2) present in excessive amounts on the surface of some cancer cells. It is ...

A Clinical and Economic Evaluation of Selective Serotonin Reuptake Inhibitors in Major Depression

Last Updated: December 1, 1997
Result type: Reports

This overview is based primarily on the technical reports "Selective Serotonin Reuptake Inhibitors (SSRIs) for Major Depression - Part 1: Evaluation of the Clinical Literature and Part II: The Cost-effectiveness of SSRIs in Treatment of Depression". Depression is a common psychiatric disorder which has significant health and cost implications f...

The efficacy of tacrine and the measurement of outcomes in Alzheimer’s disease

Last Updated: January 1, 1997
Result type: Reports

Cite as: Glennie JL. The efficacy of tacrine and the measurement of outcomes in Alzheimer's disease. Ottawa: Canadian Coordinating Office for Health Technology Assessment (CCOHTA); 1997. Background Alzheimer's disease (AD) is a disorder associated with progressive decline in memory and cognitive function. It is the most common cause of dementi...

Coronary Stents: Clinical Experience and Cost-effectiveness

Last Updated: January 1, 1997
Result type: Reports

Cite as: Noorani HZ. Coronary stents: clinical experience and cost-effectiveness. Ottawa: Canadian Coordinating Office for Health Technology Assessment (CCOHTA); 1997. Coronary stents are of value for the treatment of acute or threatened coronary artery closure complicating PTCA. Short-term clinical and angiographic outcomes are comparable with...

Macrolides in Community-acquired Pneumonia and Otitis Media

Last Updated: January 1, 1997
Result type: Reports

Cite as: Perras C. Macrolides in community-acquired pneumonia and otitis media. Ottawa: Canadian Coordinating Office for Health Technology Assessment (CCOHTA); 1997. Background The use of erythromycin is limited by its side effect profile, its weak activity against gram negative pathogens and its dosing schedule. In comparison, azithromycin an...

HMG-CoA reductase inhibitors: a review of published clinical trials and pharmacoeconomic evaluations

Last Updated: January 1, 1997
Result type: Reports

The present study is a review of published clinical trials and pharmacoeconomic evaluations of lipid-lowering agents, focusing mainly on HMG-CoA reductase inhibitors. This review is summarized throughout the text by summary points and propositions. The report discusses the relationship between lipids and coronary events. It then examines the im...

Selective serotonin reuptake inhibitors (SSRIs) for major depression. Part I: evaluation of the clinical literature

Last Updated: January 1, 1997
Result type: Reports

162 randomized controlled trials that compare selective serotonin reuptake inhibitors (SSRIs) to placebo or other antidepressants were reviewed. Meta-analyses were undertaken to compare (i) efficacy, (ii) completion rates, and (iii) adverse effects of individual drugs and drug classes. Efficacy (as measured by change in the Hamilton Rate Scale ...