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Stool Antigen Tests for Helicobacter pylori Infection: A Review of Clinical and Cost-Effectiveness and Guidelines

Last updated: January 8, 2015
Project Number: RC0620-000
Product Line: Rapid Response
Research Type: Devices and Systems
Report Type: Summary with Critical Appraisal
Result type: Report

Question

  1. What is the diagnostic accuracy and clinical effectiveness of stool antigen tests in patients with suspected H. pylori infections?
  2. What is the cost-effectiveness of stool antigen tests in patients with suspected H. pylori infections?
  3. What are the evidence-based guidelines associated with stool antigen tests in patients with suspected H. pylori infections?

Key Message

Certain commercially available stool antigen tests with high test performance (sensitivity and specificity) provide reliable results in the diagnosis of H. pylori infection and in follow-up testing after eradication therapy. The use of a stool antigen test-and-treat strategy in relieving symptoms of dyspepsia or reducing the burden of gastric cancer and peptic ulceration was cost-effective. Guidelines recommend a laboratory-based validated monoclonal stool test for test-and-treat strategies and for follow-up testing after eradication therapy.