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Thrombolytics for Patients with Acute or Massive Pulmonary Embolisms: Clinical Effectiveness and Guidelines

Last updated: August 27, 2019
Project Number: RB1385-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Summary of Abstracts
Result type: Report

Question

  1. What is the clinical effectiveness of thrombolytics for the treatment of adults with acute or emergent massive pulmonary embolism?
  2. What are the evidence-based guidelines regarding thrombolytics in managing adult patients with acute or emergent massive pulmonary embolism?

Key Message

Three systematic reviews with meta-analyses, seven meta-analyses, five randomized controlled trials, and one non-randomized study were identified regarding the clinical effectiveness of thrombolytics for the treatment of adults with acute or emergent massive pulmonary embolism. Three evidenced-based guidelines were identified regarding thrombolytics in managing adult patients with acute or emergent massive pulmonary embolism.