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Topical NSAIDs versus Opioids for Acute Musculoskeletal Pain: A Review of the Clinical Effectiveness

Published on: January 30, 2017
Project Number: RC0844-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Summary with Critical Appraisal
Result type: Report

Question

  1. What is the comparative clinical effectiveness of topical NSAIDs versus opioids for the treatment of acute musculoskeletal pain?

Key Message

Compared with placebo, topical NSAIDs were effective in reducing pain from acute musculoskeletal conditions, such as sprains, strains or sport injuries. Adverse events were rare and were usually related to skin reactions. No evidence regarding the comparative clinical effectiveness of topical NSAIDs versus opioids could be identified.

Tags

anesthesia, administration, topical, anti-inflammatory agents, non-steroidal, musculoskeletal pain, musculoskeletal