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Use of Metformin in Patients with Type 2 Diabetes who have Liver Dysfunction: A Review of Safety, Dosing Recommendations, and Guidelines for Use

Last updated: September 3, 2008
Product Line: Rapid Response
Research Type: Drug
Result type: Report

Question

  1. Is there evidence to support decisions on when therapy with metformin should be withheld based on liver function in patients with type 2 diabetes?
  2. What are the guidelines for the use of metformin in individuals with type 2 diabetes and liver dysfunction?
  3. How safe is metformin compared with other oral hypoglycemic drugs when used in individuals with type 2 diabetes and liver dysfunction?
  4. Is there clinical evidence to support dosing recommendations for metformin when used in individuals with type 2 diabetes and liver dysfunction?