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COMPUS Expert Review Committee (CERC) – Warfarin

Last updated: March 19, 2015
Result type: Report


Participating CERC Members

Public Members

Specialist Members


Lisa Dolovich, BScPhm, PharmD, MSc

Dr. Lisa Dolovich is an academic pharmacist with a primary appointment as the Research Director and an Associate Professor in the Department of Family Medicine at McMaster University. She holds cross-appointments to the Departments of Medicine and Clinical Epidemiology & Biostatistics at McMaster University. Dr. Dolovich is a scientist at the Centre for Evaluation of Medicines, a multidisciplinary research group whose aim is to promote the best use of drug and therapeutic interventions in the delivery of health care through research and educational activities. She leads a research training program called the Drug Safety and Effectiveness Cross-Disciplinary Training (DSECT; Program. DSECT is a Canadian Institutes of Health Research (CIHR) training program in bridging scientific domains for drug safety and effectiveness. The goal of the DSECT Program is to provide a training environment for future scientists in Canada to produce new knowledge related to the generation and use of safe and effective medications.

Dr. Dolovich has expertise in both qualitative and quantitative research methods, systematic overviews, and meta-analyses, as well as various areas related to health services interventions, educational interventions, drug use evaluation, and pharmacy practice.

Participating CERC Members

Scott Klarenbach, MD, MSc, FRCPC

Dr. Scott Klarenbach is an Associate Professor and Clinician Scientist in the Department of Medicine at the University of Alberta. Dr. Klarenbach received his medical training at the University of Alberta, and completed his MSc in Health Economics at the University of York, United Kingdom. He holds a Population Health Investigator Award from the Alberta Heritage Foundation for Medical Research/ Alberta Innovates – Health Solutions.

Dr. Klarenbach’s research interests are in health outcomes research and health economics research. He has conducted numerous economic evaluations and health technology assessments for both chronic and acute conditions, and has received operating grants from the Kidney Foundation of Canada and Canadian Institutes of Health Research.

Dr. Klarenbach has conducted health technology assessments for CADTH, undertaken pharmacoeconomic reviews for CADTH’s Common Drug Review, and has served on the COMPUS Expert Review Committee since its inception.

James Silvius, BA (Oxon), MD, FRCPC

Dr. Jim Silvius is an Associate Professor in the Department of Medicine, Division of Geriatric Medicine, at the University of Calgary. He obtained his BA in Physiology and Psychology from Oxford University in the United Kingdom, his MD and Specialty in Internal Medicine from the University of Alberta, and his Specialty in Geriatric Medicine from Dalhousie University. He is currently Senior Medical Director, Seniors’ Health, Alberta Health Services, based in Calgary. He maintains a clinical practice in Geriatrics at the Rockyview General Hospital. His primary research interests are in dementia care, although he also has an active interest in care delivery; he led the development of the Telehealth Outreach Program for the Department of Medicine, University of Calgary, until 2007.

Dr. Silvius has been a member of the Alberta Health and Wellness Expert Committee on Drug Evaluation and Therapeutics since 1999 and its Chair since 2004. He is the current Chair of the Alberta Medical Association’s Health Issues Council and former Alberta representative to the CMA Committee on Health Care and Promotion. He was also a former member of the Alberta Advisory Committee on Health Technologies.

Michael Allen, MD, MSc

Dr. Allen is Director, Evidence-based Programs, and Associate Professor at Dalhousie University Continuing Medical Education. Prior to beginning his current position in 1994, he worked as a family physician in rural and urban areas of Nova Scotia for 17 years. Dr. Allen has developed many educational interventions for rural and urban health professionals in Nova Scotia, including physicians, pharmacists, and dentists. He helped start the Dalhousie Academic Detailing Service and was also instrumental in the formation of the Canadian Academic Detailing Collaboration. Dr. Allen has chaired and is a member of the Drug Evaluation Alliance of Nova Scotia and is a member of the Scientific Council of Evidence-based Medicine International Canada.

Michael Evans, MD, CCFP

Dr. Evans is an Associate Professor at the University of Toronto in the Department of Family and Community Medicine, as well as a family physician. His academic work has focused on innovative solutions for making evidence-based decisions easier for both patients and primary care clinicians.

Dr. Evans launched the Mini-Med School in 2004, which won the 2007 Healthy U of T Award for its impact on the Toronto community. He is a founding member of the Centre for Effective Practice and was chair of the Ontario Program for Optimal Therapeutics Guidelines. He was also a Scientific Officer for Knowledge Translation and Exchange at the Canadian Institutes of Health Research, and was a member of Ontario's Drug Quality and Therapeutics Committee. Dr. Evans’ is the health columnist for the Life section of the Globe and Mail, a regular commentator on CBC Newsworld, and the Chief Editor of He is founder of Health Knowledge Central, a multimedia resource for busy clinicians, and the Chief Editor for the Family Practice Sourcebook, the top-selling primary care textbook in Canada. Dr. Evans is currently launching the Health Media and Innovation Lab at the new Li Ka Shing Knowledge Institute of St. Michael’s Hospital in Toronto.

Adil Virani, BSc Pharm, PharmD, FCSHP

Dr. Virani is a Director of Pharmacy Services with the Fraser Health Authority, Vancouver Coastal Health, Providence Health Care, and Provincial Health Services Authority, where he is responsible for the Professional Practice portfolio, Residency and Student Education, Academic Detailing, and pharmacy operations at Burnaby Hospital. He is an Associate Professor with the Faculty of Pharmaceutical Sciences at the University of British Columbia and coordinates a therapeutics course for third-year pharmacy students and psychiatry residents in the Faculty of Medicine. Dr. Virani has published over 30 articles, has delivered over 100 presentations, and is the lead editor of the Clinical Handbook of Psychotropic Drugs, now in its 18th edition, and the 2009 American Journal of Nursing Book of the Year. He was also co-author of the Clinical Handbook of Psychotropic Drugs for Children and Adolescents (2nd edition). Dr. Virani is a member of the Education Working Group of the Therapeutics Initiative in British Columbia, a member of the Human Drug Advisory Panel of the Patented Medicine Prices Review Board, and a Fellow of the Canadian Society of Hospital Pharmacists.

Public Members

Panos Petrides, BSc, BA, MPA

Mr. Petrides is the founder and principal of a Toronto-based private consulting company engaged in conflict resolution, government relations, and public policy. He was a Special Advisor to the Chief Commissioner of the Ontario Human Rights Commission and an Executive Assistant to the Ontario Assistant Deputy Minister of the Environment. Mr. Petrides is currently a member of the Consent and Capacity Board of the Ontario Ministry of Health and Long-Term Care. He is serving on CERC as a public member, representing the broader public interest in the proceedings of this committee.

Cathy MacNutt, BA, PMP

Mrs. MacNutt is a project manager involved in geriatric medicine research. She is a former Deputy Minister of Health for the province of Nova Scotia, Deputy National Director of Operations for Blood Services, and former Deputy Minister of Consumer Affairs in Nova Scotia. She has worked in public and private sector operations, including health services delivery, project management, corporate governance, strategic planning, and organizational development. Mrs. MacNutt is serving on CERC as a public member, bringing a lay perspective to the proceedings.

Specialist Members

Marc Carrier, MD, MSc

Dr. Carrier is a clinician scientist specializing in thrombosis. His clinical research is focused in venous thromboembolic disease and cancer, including cancer screening, prevention, and management. He holds a T2 Research Chair from the University of Ottawa on Cancer and Thrombosis. Dr. Carrier is receiving research funding from the Canadian Institutes of Health Research and the Heart and Stroke Foundation of Canada.

Agnes Y. Lee, MD, MSc

Dr. Lee is the Director of the Thrombosis Program at the University of British Columbia and is an Associated Professor in the Division of Hematology. She is a consultant hematologist at the Vancouver General Hospital and BC Cancer Agency. Dr. Lee completed her hematology training and obtained a Masters in Health Research Methodology at McMaster University.  She has held several awards including a New Investigator Award from the Canadian Institutes of Health Research/Rx&D Research Program, and Research Fellowships from the Heart and Stroke Foundation of Canada.

Dr. Lee’s research interest is in thrombotic disease in high-risk populations, with a focus on venous thromboembolism in patients with malignancy. She was the co-principal investigator of the CLOT in Cancer trial, a landmark study that established low–molecular-weight heparin as the treatment of choice for preventing recurrent venous thromboembolism in cancer patients. Her other research activities include studies in catheter-related thrombosis, diagnosis of deep vein thrombosis and pulmonary embolism in pregnant women, and thromboprophylaxis. She is also involved in translational research exploring the role of coagulation in cancer biology and has an interest in phase II/III development of novel anticoagulants.

Jafna Cox, MD

Dr. Jafna Cox obtained his MD in 1988 and trained in internal medicine at the University of Toronto.  Following a fellowship in cardiology at Dalhousie University, Dr. Cox completed post-doctoral training in health services research at the Institute for Clinical Evaluative Sciences in Ontario from 1993-1995.  He returned to Halifax in 1995 and is currently Director of Research in the Division of Cardiology, Dalhousie University, and the Heart and Stroke Foundation Endowed Chair in Cardiovascular Outcomes.

Since moving to Nova Scotia, Dr. Cox has been active in research relating to health services, outcomes, and disease management. His research focus has recently shifted to the prevention of cardiovascular disease at the primary care level, to understanding how differing provincial drug policies may be having a variable effect on patient health outcomes, and to the rapid and effective translation of available research knowledge into clinical practice. Dr. Cox has had specific experience with large public-private research partnerships, as well as with population-based, province-wide studies involving outcomes management and knowledge translation. He was a consultant to the New Brunswick Government regarding tertiary cardiovascular services in that province and currently serves as the Scientific Advisor to the Government of Nova Scotia’s cardiac care program — Cardiovascular Health Nova Scotia — a role that has increasingly become a major focus of his.

Mario Talajic, MD, FRCPC

Dr. Talajic is a cardiac electrophysiologist at the Montreal Heart Institute and is currently the JC Edwards Professor of Medicine at the University of Montreal. He is also the Chair of the Department of Medicine at the Université de Montréal and is the Director of the Cardiovascular Genetics Centre of the Montreal Heart Institute. His research interests include the pharmacologic treatment of cardiac arrhythmias, the treatment of patients with atrial fibrillation, and the stratification of patients at risk for sudden death.

Dr. Talajic completed his medical training at the University of Ottawa in 1980, and internal medicine and cardiology training at McGill University in 1985. He subsequently completed fellowship training in cardiac electrophysiology at McGill University with Dr. Stanley Nattel and at the University of Limburg under the guidance of Professor Hein Wellens. He has been a cardiac electrophysiologist at the Montreal Heart Institute since 1987 and became the first Philippa and Marvin Carsley Cardiology Chair in 2005. He has also been a Royal College examiner in cardiology and has won teaching and career achievement awards from the Université de Montréal, and has served on multiple peer-reviewed research committees in Canada. He currently is the vice-president and president-elect of the Canadian Cardiovascular Society. Dr. Talajic has authored more than 180 peer-reviewed articles and book chapters and over 270 abstracts.

Anne Holbrook, MD, PharmD, MSc, FRCPC

Dr. Holbrook is a clinical pharmacologist and internal medicine specialist with expertise in pharmacoepidemiology, clinical trials, and drug policy. She is a Professor and Director, Division of Clinical Pharmacology & Therapeutics in the Department of Medicine at McMaster University, a Senior Scientist at the Centre for Evaluation of Medicines, and an active medical staff member at both St. Joseph’s Healthcare Hamilton and Hamilton Health Sciences.

Dr. Holbrook has broad experience and expertise in evidence-based therapeutics research, education, and practice, particularly involving patients with the most complicated medical histories and drug therapy regimens. She is currently an investigator for eight peer-reviewed grants including six from CIHR. She has chaired and held appointments with numerous federal, provincial, and regional drug advisory committees.

Leslie Zypchen, MD

Dr. Leslie Zypchen is a hematologist and Clinical Assistant Professor at Vancouver General Hospital and at the University of British Columbia. She practices general hematology and has a particular interest in thrombosis. She is the manager of the Thrombosis Clinic at Vancouver General Hospital and has helped develop protocols for managing acute venous thromboembolism and perioperative anticoagulation. She is currently involved in research regarding the new oral anticoagulants and is the recent recipient of a Vancouver Coastal Health Research Institute Team Grant addressing some of the practical aspects of using these drugs.

Conflict of Interest Disclosure
All members of this committee disclosed possible conflicts of interest and were found not to have any significant ones related to this project. This process was in accordance with CADTH’s Conflict of Interest Guidelines for Members of CADTH Committees and Expert Review Panels.