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Antidepressants for Chronic Pain in Pediatric Populations: Clinical Effectiveness

Last updated: May 25, 2020
Project Number: RB1480-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Summary of Abstracts
Result type: Report

Question

  1. What is the clinical effectiveness of tricyclic antidepressants for the treatment of chronic pain in pediatric patients?
  2. What is the clinical effectiveness of serotonin-norepinephrine reuptake inhibitors for the treatment of chronic pain in pediatric patients?

Key Message

Four systematic reviews, four randomized controlled trials, and one non-randomized study were identified regarding the clinical effectiveness of tricyclic antidepressants or serotonin-norepinephrine reuptake inhibitors for the treatment of chronic pain in pediatric patients.