- What is the clinical evidence regarding methods to manage acute detoxification or withdrawal for adults who misuse methamphetamine?
- What are the evidence-based guidelines regarding the management of acute detoxification or withdrawal for adults who misuse methamphetamine?
Good quality evidence from one systematic review suggested that aripiprazole, haloperidol, and quetiapine may be effective for the management of methamphetamine-induced psychosis. Intravenous lorazepam and droperidol may be effective for the management of agitation associated with acute methamphetamine toxicity in the emergency department and isradipine may be effective for the treatment of methamphetamine-induced high blood pressure. The results of two randomized controlled trials suggested that pexacerfont and buprenorphine may be effective for managing methamphetamine craving during methamphetamine withdrawal. One evidence-based guideline recommends benzodiazepines should be considered as a first line treatment option for the management of severe agitation, aggressiveness, or psychosis stemming from methamphetamine intoxication.