pertuzumab

Generic Name: pertuzumab

Brand Name: Perjeta

Manufacturer: Hoffmann-La Roche Limited

Therapeutic Area: Early stage breast cancer

Indications: Perjeta in combination with trastuzumab and chemotherapy for the neoadjuvant treatment of patients with HER2-positive, locally advanced, inflammatory, or early stage breast cancer (either 2 cm in diameter or node positive).

Manufacturer Requested Reimbursement Criteria¹: Pertuzumab in combination with trastuzumab and chemotherapy for the neoadjuvant treatment of patients with HER2-positive, locally advanced, inflammatory, or early stage breast cancer (either 2 cm in diameter or node positive). Patients should receive neoadjuvant treatment with pertuzumab in combination with trastuzumab and chemotherapy for three to six cycles depending on the regimen chosen. Patients who start pertuzumab in combination with trastuzumab and chemotherapy in the neoadjuvant setting and do not have residual disease following surgery should continue to receive adjuvant trastuzumab to complete one year of HER2-directed therapy.

Submission Type: Initial

Tumour Type: Breast

NOC Status at Filing: Post NOC

Project Status: Active

Companion Diagnostics: No

Fee Schedule¹: Schedule A

1. The requested reimbursement criteria are provided by the applicant and do not necessarily reflect the views of CADTH. Reimbursement criteria from CADTH will be documented in the final recommendation, if applicable.