Primary membranous nephropathy (MN) is an autoimmune disease that commonly presents as nephrotic syndrome.
The treatment goal of primary MN is to achieve proteinuria remission to prevent renal damage. The current guidelines recommend immunosuppressive therapies such as cyclophosphamide and calcineurin inhibitors (cyclosporine or tacrolimus) to treat this condition. More recently, a randomized controlled trial showed that rituximab was effective in inducing and maintaining proteinuria remission. Its place in therapy compared with currently recommended immunosuppressive therapies is unclear. This Health Technology Assessment will review the available evidence on the use of rituximab for primary MN to determine its place in therapy and its cost-effectiveness relative to cyclophosphamide and calcineurin inhibitors.
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