CADTH is committed to supporting Canada’s health care decision-makers through this challenging and uncertain time.
For evidence, tools, and resources related to COVID-19, visit our COVID-19 Evidence Portal.


Begin main content

Hybrid Closed-Loop Insulin Delivery Systems for People with Type 1 Diabetes

Last updated: August 26, 2020
Project Number: OP0548-000
Product Line: Optimal Use
Project Status: In Progress
Result type: Report

Hybrid closed-loop insulin delivery systems (HCLs) are an emerging technology for the management of type 1 diabetes. HCLs combine an insulin pump with a continuous glucose monitor (CGM) and a computer program. Together, these use information from the CGM to automatically determine insulin needs throughout the day and keep the user within a pre-determined blood glucose range. They are called hybrid systems because users must still manually account for insulin needs before and after meals.
It has been noted that, across Canada, technologies to manage type 1 diabetes are rapidly evolving. There is a need to understand the place in care, if any, HCLs may have compared with existing technologies.
CADTH will undertake an Optimal Use project to assess the safety and clinical effectiveness, perspectives and experiences of users and health care providers, ethical considerations, and implementation issues of HCLs in people with type 1 diabetes. A review of economic considerations may also be conducted.


Projects listed as “in progress” are at various stages and points of completion. These products have different processes and timelines; therefore, the timing of posting of the final reports varies and expected completion dates may change. Find out more about Projects in Progress.

The “Projects in Progress” page on the CADTH website is updated on a seven- to eight-day cycle. Please be advised that there may be overlap between when a new report is posted online and when the section is updated. View our current Projects in Progress.