Bayesian Hierarchical Models of Basket Trials in the Context of Economic Evaluation

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Project Status:

Completed

Project Line:

Health Technology Review

Project Sub Line:

Technology Review

Project Number:

MH0020-000

Basket trials are an increasingly common approach to estimating the clinical efficacy of treatments with biomolecular targets. These treatments are typically efficacious in diseases that can affect more than 1 organ system (e.g., a gene mutation that is present in different types of cancer). Bayesian hierarchical models (BHMs) allow for information to be pooled from these basket trials. This paper summarizes the methodological approach to conducting BHMs, and their application to health economic evaluations. It contains a case study that illustrates how to incorporate data from a BHM into an economic evaluation, along with steps and key considerations for researchers and reviewers.

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Last Updated : May 31, 2024